Mice lacking global Stap1 expression do not manifest hypercholesterolemia.
Babunageswararao KanuriVincent FongApril HallerDavid Y HuiShailendra B PatelPublished in: BMC medical genetics (2020)
These results strongly suggest that STAP1 does not alter lipid levels, that a western diet did not exacerbate a lipid disorder in Stap1 deficient mice and support the contention that it is not causative for hyperlipidemia in ADH patients. These results support other published studies also questioning the role of this locus in human hypercholesterolemia.
Keyphrases
- end stage renal disease
- ejection fraction
- endothelial cells
- poor prognosis
- fatty acid
- cardiovascular events
- peritoneal dialysis
- physical activity
- high fat diet induced
- prognostic factors
- weight loss
- randomized controlled trial
- south africa
- cardiovascular disease
- systematic review
- coronary artery disease
- patient reported outcomes