High-dimensional mapping of human CEACAM1 expression on immune cells and association with melanoma drug resistance.
Yu-Hwa HuangCharles H YoonAmit K GandhiThomas HanleyCarlos CastrillonYasuyuki KondoXi LinWalter KimChao YangAmine DriouchiMichael C CarrollScott D Gray-OwenDuane R WesemannCharles G DrakeMonica M BertagnolliNicole BeaucheminRichard S BlumbergPublished in: Communications medicine (2024)
To the best of our knowledge, this work represents the first comprehensive atlas of CEACAM1 expression on immune cells in a human tumor and reveals an important correlation with treatment-resistant disease. These studies suggest that agents targeting CEACAM1 may represent appropriate partners for PD1-related pathway therapies.