Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils.

Rana Fetit Alistair Stewart McLaren Mark White Megan L Mills John Falconer Xabier Cortes-Lavaud Kathryn L Gilroy Tamsin R M Lannagan Rachel A Ridgway Colin Nixon Varushka Naiker Renee Njunge Cassie J Clarke Declan Whyte Kristina Kirschner Rene Jackstadt James C Norman Leo M Carlin Andrew D Campbell Owen James Sansom Colin W Steele

Published in: Cancer research communications (2024)

We identify two recurring neutrophil populations and demonstrate their staged evolution from health to malignancy through the IL1β/CXCL8/CXCR2 axis, allowing for immunotherapeutic neutrophil-targeting approaches to counteract immunosuppressive subtypes that emerge in metastasis.

Keyphrases

healthcare
public health
papillary thyroid
mental health
single cell
cell migration
cancer therapy
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climate change
human health