Photodynamic therapy with 5-aminolaevulinic acid and DNA damage: unravelling roles of p53 and ABCG2.
I PostiglioneF BarraS M AlojGiuseppe PalumboPublished in: Cell proliferation (2016)
Our data show that cell aptitude to defend its DNA from PDT-induced injury was mainly ruled by ABCG2 expression. These findings, while providing helpful information in predicting effectiveness of 5-ALA/PDT, may indicate a way to shift PDT from a palliative to a more effective approach in anti-cancer therapy.
Keyphrases
- photodynamic therapy
- dna damage
- cancer therapy
- fluorescence imaging
- poor prognosis
- single cell
- high glucose
- drug delivery
- oxidative stress
- diabetic rats
- systematic review
- randomized controlled trial
- circulating tumor
- cell free
- palliative care
- electronic health record
- cell therapy
- dna repair
- single molecule
- big data
- stem cells
- cancer stem cells
- endothelial cells
- drug induced
- healthcare
- health information
- mesenchymal stem cells
- binding protein
- advanced cancer
- long non coding rna
- machine learning
- deep learning
- nucleic acid