Myofilament Phosphorylation in Stem Cell Treated Diastolic Heart Failure.
Daniel SoetkampRomain GalletSarah J ParkerRonald HolewinskiVidya VenkatramanKiel PeckJoshua I GoldhaberEduardo MarbánJennifer E Van EykPublished in: Circulation research (2021)
Increased protein phosphorylation at the Z-disk is associated with diastolic dysfunction, with PKC isoforms driving most quantified phosphorylation changes. Because CDCs reverse the key abnormalities in HFpEF and selectively reverse PKCβ upregulation, PKCβ merits being classified as a potential therapeutic target in HFpEF, a disease notoriously refractory to medical intervention.
Keyphrases
- protein kinase
- left ventricular
- heart failure
- stem cells
- blood pressure
- randomized controlled trial
- healthcare
- ejection fraction
- oxidative stress
- poor prognosis
- signaling pathway
- protein protein
- risk assessment
- atrial fibrillation
- binding protein
- small molecule
- human health
- mesenchymal stem cells
- climate change
- acute heart failure