Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein (FABP1) and FABP1 Binding Alters Drug Metabolism.
King Clyde B YabutAlice MartynovaAbhinav NathBenjamin P ZercherMatthew F BushNina IsoherranenPublished in: bioRxiv : the preprint server for biology (2024)
Many commonly prescribed drugs bind FABP1 forming ternary complexes with FABP1 and the fluorescent fatty acid DAUDA. This suggests that in the human liver drugs will bind to apo-FABP1 and fatty acid bound FABP1. The high expression of FABP1 in the liver and binding of drugs to FABP1 will alter rates of drug metabolism in the liver.