Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk.
Nicole E KramerPhilip R CoryellSusan D'CostaEliza ThulsonSeyoun ByunHyunAh KimSylvie M ParkusMarielle L BondJacqueline Yalin S Shin SahinSusanna ChubinskayaMichael I LoveKaren L MohlkeBrian O DiekmanRichard F LoeserDouglas H PhanstielPublished in: bioRxiv : the preprint server for biology (2024)
∘ Comprehensive analysis of sex- and age-related global gene expression in human chondrocytes revealed differences that correlate with osteoarthritis ∘ First response eQTLs in chondrocytes treated with an OA-related stimulus ∘ Deeply sequenced Hi-C in resting and activated chondrocytes helps connect OA risk variants to their putative causal genes ∘ Colocalization analysis reveals 13 (including 10 novel) putative OA risk genes.