Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human obesity.

Sebastio PerriniStefania PorroPasquale NigroAngelo CignarelliCristina CaccioppoliValentina Annamaria GenchiGennaro MartinesMichele De FazioPalma CapuanoAnnalisa NatalicchioLuigi LaviolaFrancesco Giorgino

Published in: International journal of obesity (2005) (2019)

SIRT1 and SIRT2 modulate the differentiation of human ASC. Reduced expression of SIRT1 and SIRT2 may enhance the differentiation capacity of visceral ASC in human obesity, fostering visceral adipose tissue expansion.

Keyphrases

insulin resistance
adipose tissue
endothelial cells
stem cells
oxidative stress
induced pluripotent stem cells
ischemia reperfusion injury
metabolic syndrome
type diabetes
pluripotent stem cells
poor prognosis
weight loss
high fat diet induced
body mass index
mesenchymal stem cells
bone marrow
fatty acid