Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification.
Sam O KleemanViktor H KoelzerHelen Js JonesEster Gil VazquezHayley L Belnoue-DavisJames E EastRoland ArnoldMartijn Aj KoppensAndrew BlakeEnric DomingoChris CunninghamAndrew D BeggsValerie PestingerMaurice B LoughreyLai-Mun WangTamsin Rm LannaganSusan L WoodsDaniel WorthleyS Cort ConsortiumIan P M TomlinsonPhilip D DunneTimothy MaughanSimon J LeedhamPublished in: Gut (2019)
Epigenetic suppression of appropriate Wnt negative feedback loops is selectively advantageous in LD tumours and differential AXIN2 expression in LD/LI lesions can be exploited as a molecular biomarker. Distinguishing between LD/LI tumour types is important; patients with LD tumours retain sensitivity to Wnt ligand inhibition and may be stratified at diagnosis to clinical trials of Porcupine inhibitors.