Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer.
Ellen LangilleKhalid N Al-ZahraniZhibo MaMinggao LiangLiis Uusküla-ReimandRoderic Espin GarciaKatie TengAhmad A MalikHelga BergholtzSamah El GhamrasniSomaieh Afiuni-ZadehRicky TsaiSana AlviAndrew J EliaYiQing LüRobin Hyunseo OhKatelyn J KozmaDaniel TrckaMasahiro NarimatsuJeff C LiuThomas NguyenSeda Avcioglu BarutcuSampath Kumar LoganathanRod BremnerGary D BaiderSean E EganDavid W CesconTherese SørlieJeffrey L WranaHartland Warren JacksonMichael D WilsonAgnieszka K WitkiewiczErik S KnudsenMiguel Angel PujanaGeoffrey M WahlDaniel SchramekPublished in: Cancer discovery (2022)
Infrequently mutated genes comprise most of the mutational burden in breast tumors but are poorly understood. In vivo CRISPR screening identified functional tumor suppressors that converged on epigenetic regulation. Loss of epigenetic regulators accelerated tumorigenesis and revealed lineage infidelity and aberrant expression of alveogenesis genes as potential early events in tumorigenesis. This article is highlighted in the In This Issue feature, p. 2711.