Daniel Schramek

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 36

Top Venues

Nature communications

Nature

Molecular systems biology

Science (New York, N.Y.)

University of Toronto

New York University - School of Engineering (MSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Toronto Jul 01 2015

Canada

Assistant Professor :: Molecular Genetics, Faculty of Medicine

Lunenfeld-Tanenbaum Research Institute, Sinai Health System Apr 01 2015

Canada

Principal Investigator :: Systems Biology

The Rockefeller University & Howard Hughes Medical Institute Mar 01 2015

United States

Visiting Professor :: Laboratory of Cell Biology and Development

The Rockefeller University & Howard Hughes Medical Institute May 01 2011 - Jan 31 2015

United States

Postdoctoral Fellow & Emerald Foundation Young Investigator :: Laboratory of Molecular Cell Biology and Development

Institute of Molecular Biotechnology Austria IMBA - May 01 2011

Austria

Postdoctoral Associate :: Institute of Molecular Biotechnology Austria IMBA

Institute of Molecular Biotechnology Austria IMBA Mar 01 2006 - Jul 31 2010

Austria

Postgraduate Research Associate; PhD Student :: Austrian Academy of Science

Garvan Institute of Medical Research, University of New South Wales May 01 2004 - Dec 01 2005

Australia

Postgraduate Research Fellow, MSc Student :: Garvan Institute of Medical Research

Education History

New York University - School of Engineering Sep 01 2012 - Jul 31 2014

United States

MSC :: Management of Technology

University of Vienna & Austrian Academy of Science at IMBA Jul 01 2007 - May 01 2010

Austria

PHD :: Genetics

University of Vienna & Garvan Institute of Medical Research Sep 01 2004 - Jul 01 2006

Australia

MSC :: Molecular Biology

Vienna University Feb 01 2000 - Mar 30 2006

Austria

BSC :: Molecular Biology

Publications

Sebastien Martinez, Shifei Wu, Michael J Geuenich, Ahmad A Malik, Ramona Weber, Tristan Woo, Amy Zhang, Gun Ho Jang, Dzana Dervovic, Khalid N Al-Zahrani, Ricky Tsai, Nassima Fodil, Philippe Gros, Steven Gallinger, G Gregory Neely, Faiyaz Notta, Ataman Sendoel, Kieran R Campbell, Ulrich Elling, Daniel Schramek
In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer. Nature communications 15 (1) (2024)
Peiran Su, Yin Liu, Tianyi Chen, Yibo Xue, Yong Zeng, Guanghui Zhu, Sujun Chen, Mona Teng, Xinpei Ci, Mengdi Guo, Michael Y He, Jun Hao, Vivian Chu, Wenxi Xu, Shiyan Wang, Parinaz Mehdipour, Xin Xu, Sajid A Marhon, Fraser Soares, Nhu-An Pham, Bell Xi Wu, Peter Hyunwuk Her, Shengrui Feng, Najd Alshamlan, Maryam Khalil, Rehna Krishnan, Fangyou Yu, Chang Chen, Francis Burrows, Razqallah Hakem, Mathieu Lupien, Shane Harding, Benjamin H Lok, Catherine O'Brien, Alejandro Berlin, Daniel D De Carvalho, David G Brooks, Daniel Schramek, Ming Sound Tsao, Housheng Hansen He
In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions. Nature genetics (2024)
Juline Poirson, Hanna Cho, Akashdeep Dhillon, Shahan Haider, Ahmad Zoheyr Imrit, Mandy Hiu Yi Lam, Nader Alerasool, Jessica Lacoste, Lamisa Mizan, Cassandra Wong, Anne-Claude Gingras, Daniel Schramek, Mikko Taipale
Proteome-scale discovery of protein degradation and stabilization effectors. Nature 628 (8009) (2024)
Juline Poirson, Hanna Cho, Akashdeep Dhillon, Shahan Haider, Ahmad Zoheyr Imrit, Mandy Hiu Yi Lam, Nader Alerasool, Jessica Lacoste, Lamisa Mizan, Cassandra Wong, Anne-Claude Gingras, Daniel Schramek, Mikko Taipale
Proteome-scale discovery of protein degradation and stabilization effectors. Nature 628 (8009) (2024)
Juline Poirson, Hanna Cho, Akashdeep Dhillon, Shahan Haider, Ahmad Zoheyr Imrit, Mandy Hiu Yi Lam, Nader Alerasool, Jessica Lacoste, Lamisa Mizan, Cassandra Wong, Anne-Claude Gingras, Daniel Schramek, Mikko Taipale
Proteome-scale discovery of protein degradation and stabilization effectors. Nature (2024)
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad A Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability. Molecular systems biology (2024)
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad A Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability. Molecular systems biology 20 (6) (2024)
Juline Poirson, Hanna Cho, Akashdeep Dhillon, Shahan Haider, Ahmad Zoheyr Imrit, Mandy Hiu Yi Lam, Nader Alerasool, Jessica Lacoste, Lamisa Mizan, Cassandra Wong, Anne-Claude Gingras, Daniel Schramek, Mikko Taipale
Proteome-scale discovery of protein degradation and stabilization effectors. Nature 628 (8009) (2024)
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad A Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability. Molecular systems biology 20 (6) (2024)
Graham MacLeod, Fatemeh Molaei, Shahan Haider, Maira P Almeida, Sichun Lin, Michelle Kushida, Haresh Sureshkumar, Jasmine K Bhatti, Jack Q Lu, Daniel Schramek, Peter B Dirks, Stephane Angers
Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities. Cancer research (2024)
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad A Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability. Molecular systems biology 20 (6) (2024)
Sebastien Martinez, Shifei Wu, Michael J Geuenich, Ahmad A Malik, Ramona Weber, Tristan Woo, Amy Zhang, Gun Ho Jang, Dzana Dervovic, Khalid N Al-Zahrani, Ricky Tsai, Nassima Fodil, Philippe Gros, Steven Gallinger, G Gregory Neely, Faiyaz Notta, Ataman Sendoel, Kieran R Campbell, Ulrich Elling, Daniel Schramek
In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer. Nature communications 15 (1) (2024)
Sebastien Martinez, Shifei Wu, Michael J Geuenich, Ahmad A Malik, Ramona Weber, Tristan Woo, Amy Zhang, Gun Ho Jang, Dzana Dervovic, Khalid N Al-Zahrani, Ricky Tsai, Nassima Fodil, Philippe Gros, Steven Gallinger, G Gregory Neely, Faiyaz Notta, Ataman Sendoel, Kieran R Campbell, Ulrich Elling, Daniel Schramek
In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer. Nature communications 15 (1) (2024)
Juline Poirson, Hanna Cho, Akashdeep Dhillon, Shahan Haider, Ahmad Zoheyr Imrit, Mandy Hiu Yi Lam, Nader Alerasool, Jessica Lacoste, Lamisa Mizan, Cassandra Wong, Anne-Claude Gingras, Daniel Schramek, Mikko Taipale
Proteome-scale discovery of protein degradation and stabilization effectors. Nature (2024)
Juline Poirson, Hanna Cho, Akashdeep Dhillon, Shahan Haider, Ahmad Zoheyr Imrit, Mandy Hiu Yi Lam, Nader Alerasool, Jessica Lacoste, Lamisa Mizan, Cassandra Wong, Anne-Claude Gingras, Daniel Schramek, Mikko Taipale
Proteome-scale discovery of protein degradation and stabilization effectors. Nature (2024)
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad A Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability. Molecular systems biology 20 (6) (2024)
Sebastien Martinez, Shifei Wu, Michael J Geuenich, Ahmad A Malik, Ramona Weber, Tristan Woo, Amy Zhang, Gun Ho Jang, Dzana Dervovic, Khalid N Al-Zahrani, Ricky Tsai, Nassima Fodil, Philippe Gros, Steven Gallinger, G Gregory Neely, Faiyaz Notta, Ataman Sendoel, Kieran R Campbell, Ulrich Elling, Daniel Schramek
In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer. Nature communications 15 (1) (2024)
Juline Poirson, Hanna Cho, Akashdeep Dhillon, Shahan Haider, Ahmad Zoheyr Imrit, Mandy Hiu Yi Lam, Nader Alerasool, Jessica Lacoste, Lamisa Mizan, Cassandra Wong, Anne-Claude Gingras, Daniel Schramek, Mikko Taipale
Proteome-scale discovery of protein degradation and stabilization effectors. Nature (2024)
Nina Adler, Alexander T Bahcheli, Kevin C L Cheng, Khalid N Al-Zahrani, Mykhaylo Slobodyanyuk, Diogo Vieira da Silva Pellegrina, Daniel Schramek, Jüri Reimand
Mutational processes of tobacco smoking and APOBEC activity generate protein-truncating mutations in cancer genomes. Science advances 9 (44) (2023)
Ana Vujovic, Laura P M H de Rooij, Ava Keyvani Chahi, He Tian Tony Chen, Brian A Yee, Sampath Kumar Loganathan, Lina Liu, Derek C H Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Zaldy Balde, Soheil Jahangiri, Sasan Zandi, Stefan Aigner, John E Dick, Mark D Minden, Daniel Schramek, Gene W Yeo, Kristin J Hope
In vivo screening unveils pervasive RNA-binding protein dependencies in leukemic stem cells and identifies ELAVL1 as a therapeutic target. Blood cancer discovery (2023)
Dzana Dervovic, Ahmad A Malik, Edward L Y Chen, Masahiro Narimatsu, Nina Adler, Somaieh Afiuni-Zadeh, Dagmar Krenbek, Sebastien Martinez, Ricky Tsai, Jonathan Boucher, Jacob M Berman, Katie Teng, Arshad Ayyaz, YiQing Lü, Geraldine Mbamalu, Sampath Kumar Loganathan, Jongbok Lee, Li Zhang, Cynthia J Guidos, Jeffrey L Wrana, Arschang Valipour, Philippe P Roux, Jüri Reimand, Hartland Warren Jackson, Daniel Schramek
In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer. Nature communications 14 (1) (2023)
Ana Vujovic, Laura P M H de Rooij, Ava Keyvani Chahi, He Tian Tony Chen, Brian A Yee, Sampath Kumar Loganathan, Lina Liu, Derek C H Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Zaldy Balde, Soheil Jahangiri, Sasan Zandi, Stefan Aigner, John E Dick, Mark D Minden, Daniel Schramek, Gene W Yeo, Kristin J Hope
In vivo screening unveils pervasive RNA-binding protein dependencies in leukemic stem cells and identifies ELAVL1 as a therapeutic target. Blood cancer discovery (2023)
Dzana Dervovic, Ahmad A Malik, Edward L Y Chen, Masahiro Narimatsu, Nina Adler, Somaieh Afiuni-Zadeh, Dagmar Krenbek, Sebastien Martinez, Ricky Tsai, Jonathan Boucher, Jacob M Berman, Katie Teng, Arshad Ayyaz, YiQing Lü, Geraldine Mbamalu, Sampath Kumar Loganathan, Jongbok Lee, Li Zhang, Cynthia J Guidos, Jeffrey L Wrana, Arschang Valipour, Philippe P Roux, Jüri Reimand, Hartland Warren Jackson, Daniel Schramek
Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer. Nature communications 14 (1) (2023)
Weifan Dong, Adam Fekete, Xiaodi Chen, Hongwei Liu, Greg L Beilhartz, Xin Chen, Shahrzad Bahrampour, Yi Xiong, Qi Yang, Hongyu Zhao, Tian Kong, Malia S Morioka, Geena Jung, Ji-Eun Kim, Daniel Schramek, Peter B Dirks, Yuanquan Song, Tae-Hee Kim, Ye He, Siyi Wanggou, Xuejun Li, Roman A Melnyk, Lu-Yang Wang, Xi Huang
A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma. Nature cancer (2023)
Ilaria Panzeri, Luca Fagnocchi, Stefanos Apostle, Megan Tompkins, Emily Wolfrum, Zachary B Madaj, Galen Hostetter, Yanqing Liu, Kristen Schaefer, Yang Chih-Hsiang, Alexis Bergsma, Anne Drougard, Erez Dror, null null, Darrell Chandler, Daniel Schramek, Timothy J Triche, J Andrew Pospisilik
Developmental priming of cancer susceptibility. bioRxiv : the preprint server for biology (2023)
Ellen Langille, Khalid N Al-Zahrani, Zhibo Ma, Minggao Liang, Liis Uusküla-Reimand, Roderic Espin Garcia, Katie Teng, Ahmad A Malik, Helga Bergholtz, Samah El Ghamrasni, Somaieh Afiuni-Zadeh, Ricky Tsai, Sana Alvi, Andrew J Elia, YiQing Lü, Robin Hyunseo Oh, Katelyn J Kozma, Daniel Trcka, Masahiro Narimatsu, Jeff C Liu, Thomas Nguyen, Seda Avcioglu Barutcu, Sampath Kumar Loganathan, Rod Bremner, Gary D Baider, Sean E Egan, David W Cescon, Therese Sørlie, Jeffrey L Wrana, Hartland Warren Jackson, Michael D Wilson, Agnieszka K Witkiewicz, Erik S Knudsen, Miguel Angel Pujana, Geoffrey M Wahl, Daniel Schramek
Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer. Cancer discovery 12 (12) (2022)
Connor Yanchus, Kristen L Drucker, Thomas M Kollmeyer, Ricky Tsai, Warren Winick-Ng, Minggao Liang, Ahmad Malik, Judy Pawling, Silvana B De Lorenzo, Asma Ali, Paul A Decker, Matt L Kosel, Arijit Panda, Khalid N Al-Zahrani, Lingyan Jiang, Jared W L Browning, Chris Lowden, Michael Geuenich, J Javier Hernandez, Jessica T Gosio, Musaddeque Ahmed, Sampath Kumar Loganathan, Jacob Berman, Daniel Trcka, Kulandaimanuvel Antony Michealraj, Jerome Fortin, Brittany Carson, Ethan W Hollingsworth, Sandra Jacinto, Parisa Mazrooei, Lily Zhou, Andrew J Elia, Mathieu Lupien, Housheng Hansen He, Daniel J Murphy, Liguo Wang, Alexej Abyzov, James W Dennis, Philipp G Maass, Kieran Campbell, Michael D Wilson, Daniel H Lachance, Margaret Wrensch, John Wiencke, Tak Wah Mak, Len A Pennacchio, Diane E Dickel, Axel Visel, Jeffrey L Wrana, Michael D Taylor, Gelareh Zadeh, Peter B Dirks, Jeanette E Eckel-Passow, Liliana Attisano, Ana Pombo, Cristiane M Ida, Evgeny Z Kvon, Robert B Jenkins, Daniel Schramek
A noncoding single-nucleotide polymorphism at 8q24 drives IDH1 -mutant glioma formation. Science (New York, N.Y.) 378 (6615) (2022)
Krista Schleicher, Daniel Schramek
AJUBA: A regulator of epidermal homeostasis and cancer. Experimental dermatology 30 (4) (2021)
Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham MacLeod, Ivan Topisirovic, Louis Gaboury, Christoph J Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P Roux
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer. Nature communications 11 (1) (2020)
Sampath Kumar Loganathan, Daniel Schramek
In vivo CRISPR screens reveal potent driver mutations in head and neck cancers. Molecular & cellular oncology 7 (4) (2020)
Geoffrey G Hesketh, Fotini Papazotos, Judy Pawling, Dushyandi Rajendran, James D R Knight, Sebastien Martinez, Mikko Taipale, Daniel Schramek, James W Dennis, Anne-Claude Gingras
The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids. Science (New York, N.Y.) 370 (6514) (2020)
Sampath Kumar Loganathan, Krista Schleicher, Ahmad Malik, Rene Quevedo, Ellen Langille, Katie Teng, Robin H Oh, Bhavisha Rathod, Ricky Tsai, Payman Samavarchi-Tehrani, Trevor J Pugh, Anne-Claude Gingras, Daniel Schramek
Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling. Science (New York, N.Y.) 367 (6483) (2020)
Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J Cronin, Zhigang She, Franz Quehenberger, Helmut H Popper, Lukas Kenner, Jody J Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer, Josef M Penninger
AIF-regulated oxidative phosphorylation supports lung cancer development. Cell research 29 (7) (2019)
Krzysztof Chylinski, Maria Hubmann, Ruth E Hanna, Connor Yanchus, Georg Michlits, Esther C H Uijttewaal, John G Doench, Daniel Schramek, Ulrich Elling
CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci. Nature communications 10 (1) (2019)
Ryan J O Dowling, Joseph A Sparano, Pamela J Goodwin, Francois-Clement Bidard, David W Cescon, Sarat Chandarlapaty, Joseph O Deasy, Mitch Dowsett, Robert C Gray, Norah L Henry, Funda Meric-Bernstam, Jane Perlmutter, George W Sledge, Mangesh A Thorat, Scott V Bratman, Lisa Anne Carey, Martin C Chang, Angela DeMichele, Marguerite Ennis, Katarzyna J Jerzak, Larissa A Korde, Ana Elisa Lohmann, Eleftherios P Mamounas, Wendy R Parulekar, Meredith M Regan, Daniel Schramek, Vuk Stambolic, Timothy J Whelan, Antonio C Wolff, James R Woodgett, Kevin Kalinsky, Daniel F Hayes
Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions. JNCI cancer spectrum 3 (4) (2019)
Ryan J O Dowling, Kevin Kalinsky, Daniel F Hayes, Francois-Clement Bidard, David W Cescon, Sarat Chandarlapaty, Joseph O Deasy, Mitch Dowsett, Robert C Gray, Norah L Henry, Funda Meric-Bernstam, Jane Perlmutter, George W Sledge, Scott V Bratman, Lisa Anne Carey, Martin C Chang, Angela DeMichele, Marguerite Ennis, Katarzyna J Jerzak, Larissa A Korde, Ana Elisa Lohmann, Eleftherios P Mamounas, Wendy R Parulekar, Meredith M Regan, Daniel Schramek, Vuk Stambolic, Mangesh A Thorat, Timothy J Whelan, Antonio C Wolff, James R Woodgett, Joseph A Sparano, Pamela J Goodwin
Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations. JNCI cancer spectrum 3 (4) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Daniel Schramek