Increased ILT2 + natural killer T cells correlate with disease activity in systemic lupus erythematosus.
Ning ChenYijun DaiHui LiXianming LongJun KeJiuyun ZhangHong SunFei GaoHe LinQing YanPublished in: Clinical rheumatology (2023)
NKT cells have a vital function in the immune abnormalities of SLE, which can also supply a viable goal for therapeutic intervention. Key Points •ILT2 expression was significantly increased in NKT cells in SLE patients. •ILT2+ NKT cell frequencies were associated with clinical severity which may be used as an indicator for evaluating disease activity in patients with SLE.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- induced apoptosis
- juvenile idiopathic arthritis
- cell cycle arrest
- end stage renal disease
- randomized controlled trial
- newly diagnosed
- chronic kidney disease
- poor prognosis
- ejection fraction
- endoplasmic reticulum stress
- single cell
- prognostic factors
- signaling pathway
- cell death
- mesenchymal stem cells
- patient reported outcomes
- oxidative stress
- long non coding rna
- pi k akt
- binding protein