STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis.

Ruby E DawsonVirginie DeswaerteAlison C WestKe TangAlice J WestJesse J BalicLinden J GearingMohamed I SaadLiang YuYonghui WuPrithi S BhathalBeena KumarJayati T ChakrabartiYana ZavrosHiroko OshimaDennis M KlinmanMasanobu OshimaPatrick Boon-Ooi Tan Brendan J Jenkins

Published in: Gut (2021)

AIM2 can play a driver role in epithelial carcinogenesis by linking cytokine-STAT3 signalling, innate immunity and epithelial cell migration, independent of inflammasome activation.

Keyphrases

cell migration
cell proliferation
poor prognosis
circulating tumor
signaling pathway
single molecule
nucleic acid