G protein-coupled receptor 40 expression in human melanoma - correlation with tumour thickness, AJCC stage and survival.

Johannes KleemannI HrgovicP KleimannJ Ter-NeddenM GlaserK SteinhorstK HärleJ MüllerR KaufmannStefan KippenbergerM Meissner

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2019)

The present study identified GPR40 as a novel target molecule in melanoma. First evidence for a potential role of the receptor in tumour progression and metastases was found, and it could be demonstrated that GPR40 expression is negatively correlated with patient's survival.

Keyphrases

poor prognosis
endothelial cells
binding protein
fatty acid
case report
skin cancer
risk assessment
basal cell carcinoma
pluripotent stem cells