Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study.
Samuel M BrownSarah J BeesleyChris StubbenEmily L WilsonAngela P PressonColin GrissomColin MaguireMatthew T RondinaRamona O HopkinsPublished in: Journal of intensive care medicine (2020)
In this prospective pilot cohort, executive dysfunction affected 1 in 5 survivors of sepsis. The APOE gene was sparsely transcribed in peripheral leukocytes and not associated with cognitive impairment. Future lines of research are suggested.
Keyphrases
- cognitive impairment
- peripheral blood
- cognitive decline
- septic shock
- acute kidney injury
- intensive care unit
- high fat diet
- mild cognitive impairment
- poor prognosis
- young adults
- oxidative stress
- copy number
- working memory
- study protocol
- randomized controlled trial
- cross sectional
- white matter
- binding protein
- adipose tissue
- clinical trial
- skeletal muscle
- insulin resistance
- chemotherapy induced