Transcriptional Plasticity Drives Leukemia Immune Escape.
Kenneth EagleTaku HaradaJérémie KalfonMonika W PerezYaser HeshmatiJazmin EwersJošt Vrabič KorenJoshua M DempsterGuillaume KugenerVikram R ParalkarCharles Y LinNeekesh V DhariaKimberly StegmaierStuart H OrkinMaxim PimkinPublished in: Blood cancer discovery (2022)
Our findings point to an adaptive transcriptional mechanism of AML evolution after allogeneic transplantation whereby combinatorial fluctuations of TF expression under immune pressure result in the selection of cells with a silenced T-cell stimulation program. This article is highlighted in the In This Issue feature, p. 369.
Keyphrases
- acute myeloid leukemia
- bone marrow
- induced apoptosis
- gene expression
- transcription factor
- poor prognosis
- stem cell transplantation
- cell cycle arrest
- machine learning
- quality improvement
- heat shock
- deep learning
- cell therapy
- cell death
- stem cells
- signaling pathway
- oxidative stress
- binding protein
- long non coding rna
- acute lymphoblastic leukemia
- hematopoietic stem cell
- mesenchymal stem cells
- pi k akt