Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2.
Tia A TumminoVeronica V RezeljBenoit FischerAudrey FischerMatthew J O'MearaBlandine MonelThomas ValletZiyang ZhangAssaf AlonHenry R O'DonnellJiankun LyuHeiko SchadtKris M WhiteNevan J KroganLaszlo UrbanKevan M ShokatAndrew C KruseAdolfo García-SastreOlivier SchwartzFrancesca MorettiMarco VignuzziFrancois PognanBrian K ShoichetPublished in: bioRxiv : the preprint server for biology (2021)
Drug-induced phospholipidosis is a single mechanism that may explain the in vitro efficacy of a wide-variety of therapeutics repurposed for COVID-19.