Kevan M Shokat (K Shokat, Kevan Shokat)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 47

Top Venues

Nature chemical biology

Nature cancer

Science (New York, N.Y.)

Nature

UCSF Medical Center

UC Berkeley College of Chemistry (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

UCSF Medical Center Jun 01 1994

United States

Professor :: Cellular and Molecular Pharmacology

Education History

UC Berkeley College of Chemistry Sep 01 1986 - Oct 01 1991

United States

PHD :: Chemistry

Publications

Qinheng Zheng, Ziyang Zhang, Keelan Z Guiley, Kevan M Shokat
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nature chemical biology 20 (9) (2024)
Jonathan M L Ostrem, Ulf Peters, Kevan M Shokat
Direct RAS inhibitors turn 10. Nature chemical biology (2024)
Qinheng Zheng, Ziyang Zhang, Keelan Z Guiley, Kevan M Shokat
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nature chemical biology (2024)
Qinheng Zheng, Ziyang Zhang, Keelan Z Guiley, Kevan M Shokat
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nature chemical biology 20 (9) (2024)
J E Le Belle, M Condro, C Cepeda, K D Oikonomou, K Tessema, L Dudley, J Schoenfield, R Kawaguchi, D Geschwind, A J Silva, Z Zhang, Kevan M Shokat, N G Harris, H I Kornblum
Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity. bioRxiv : the preprint server for biology (2024)
Qinheng Zheng, Ziyang Zhang, Keelan Z Guiley, Kevan M Shokat
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nature chemical biology 20 (9) (2024)
Morteza Malakoutikhah, Randa Mahran, Negin Gooran, Ahmadreza Masoumi, Katri Lundell, Arto Liljeblad, Keelan Guiley, Shizhong A Dai, Qinheng Zheng, Lawrence Zhu, Kevan M Shokat, Kari Kopra, Harri Härmä
Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes. Analytical chemistry (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer 4 (2) (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer 4 (2) (2023)
Kelsey M Haas, Michael J McGregor, Mehdi Bouhaddou, Benjamin J Polacco, Eun-Young Kim, Thong T Nguyen, Billy W Newton, Matthew Urbanowski, Heejin Kim, Michael A P Williams, Veronica V Rezelj, Alexandra Hardy, Andrea Fossati, Erica J Stevenson, Ellie Sukerman, Tiffany Kim, Sudhir Penugonda, Elena Moreno, Hannes Braberg, Yuan Zhou, Giorgi Metreveli, Bhavya Harjai, Tia A Tummino, James E Melnyk, Margaret Soucheray, Jyoti Batra, Lars Pache, Laura Martin-Sancho, Jared Carlson-Stevermer, Alexander S Jureka, Christopher F Basler, Kevan M Shokat, Brian K Shoichet, Leah P Shriver, Jeffrey R Johnson, Megan L Shaw, Sumit K Chanda, Dan M Roden, Tonia C Carter, Leah C Kottyan, Rex L Chisholm, Jennifer Allen Pacheco, Maureen E Smith, Steven J Schrodi, Randy A Albrecht, Marco Vignuzzi, Lorena Zuliani-Alvarez, Danielle L Swaney, Manon Eckhardt, Steven M Wolinsky, Kris M White, Judd F Hultquist, Robyn M Kaake, Adolfo García-Sastre, Nevan J Krogan
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets. Nature communications 14 (1) (2023)
Olena Zhulyn, Hannah D Rosenblatt, Leila Shokat, Shizhong Dai, Duygu Kuzuoğlu-Öztürk, Zijian Zhang, Davide Ruggero, Kevan M Shokat, Maria Barna
Evolutionarily divergent mTOR remodels translatome for tissue regeneration. Nature (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer 4 (2) (2023)
Johannes Morstein, Rebika Shrestha, Que N Van, César A López, Neha Arora, Marco Tonelli, Hong Liang, De Chen, Yong Zhou, John F Hancock, Andrew G Stephen, Thomas J Turbyville, Kevan M Shokat
Direct Modulators of K-Ras-Membrane Interactions. ACS chemical biology (2023)
Federica Liccardo, Johannes Morstein, Ting-Yu Lin, Julius Pampel, Kevan M Shokat, Roshanak Irannejad
Selective activation of intracellular β1AR using a spatially restricted antagonist. bioRxiv : the preprint server for biology (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer 4 (2) (2023)
Ziyang Zhang, Qiwen Fan, Xujun Luo, Kevin Lou, William A Weiss, Kevan M Shokat
Brain-restricted mTOR inhibition with binary pharmacology. Nature 609 (7928) (2022)
Ziyang Zhang, Keelan Z Guiley, Kevan M Shokat
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nature chemical biology 18 (11) (2022)
D Matthew Peacock, Mark J S Kelly, Kevan M Shokat
Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy. ACS chemical biology 17 (10) (2022)
Keelan Z Guiley, Kevan M Shokat
A small molecule reacts with the p53 somatic mutant Y220C to rescue wild-type thermal stability. Cancer discovery (2022)
Lisa Werr, Dennis Plenker, Marcel A Dammert, Carina Lorenz, Johannes Brägelmann, Hannah L Tumbrink, Sebastian Klein, Anna Schmitt, Reinhard Büttner, Thorsten Persigehl, Kevan M Shokat, F Thomas Wunderlich, Alison M Schram, Martin Peifer, Martin L Sos, Hans Christian Reinhardt, Roman K Thomas
CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization. Molecular cancer therapeutics 21 (5) (2022)
Qinheng Zheng, D Matthew Peacock, Kevan M Shokat
Drugging the Next Undruggable KRAS Allele-Gly12Asp. Journal of medicinal chemistry 65 (4) (2022)
Ziyang Zhang, Johannes Morstein, Andrew K Ecker, Keelan Z Guiley, Kevan M Shokat
Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile. Journal of the American Chemical Society 144 (35) (2022)
Geoffrey Alexander Smith, Arun Padmanabhan, Bryan H Lau, Akhil Pampana, Li Li, Clara Youngna Lee, Angelo Pelonero, Tomohiro Nishino, Nandhini Sadagopan, Vivian Q Xia, Rajan Jain, Pradeep Natarajan, Roland S Wu, Brian L Black, Deepak Srivastava, Kevan M Shokat, John S Chorba
Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Science translational medicine 14 (662) (2022)
James E Melnyk, Veronica Steri, Hao G Nguyen, Y Christina Hwang, John D Gordan, Byron Hann, Felix Y Feng, Kevan M Shokat
Targeting a splicing-mediated drug resistance mechanism in prostate cancer by inhibiting transcriptional regulation by PKCβ1. Oncogene 41 (11) (2022)
Ross L Cagan, Kevan M Shokat
Drugging the undruggable: Ross Cagan interviews Kevan Shokat. Disease models & mechanisms 15 (2) (2022)
James D Vasta, D Matthew Peacock, Qinheng Zheng, Joel A Walker, Ziyang Zhang, Chad A Zimprich, Morgan R Thomas, Michael T Beck, Brock F Binkowski, Cesear R Corona, Matthew B Robers, Kevan M Shokat
KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nature chemical biology 18 (6) (2022)
Kevin Lou, Douglas R Wassarman, Tangpo Yang, YiTing Paung, Ziyang Zhang, Thomas A O'Loughlin, Megan K Moore, Regina K Egan, Patricia Greninger, Cyril H Benes, Markus A Seeliger, Jack Taunton, Luke A Gilbert, Kevan M Shokat
IFITM proteins assist cellular uptake of diverse linked chemotypes. Science (New York, N.Y.) 378 (6624) (2022)
Xiaochao Tan, Priyam Banerjee, Edward A Pham, Florentine U N Rutaganira, Kaustabh Basu, Neus Bota-Rabassedas, Hou-Fu Guo, Caitlin L Grzeskowiak, Xin Liu, Jiang Yu, Lei Shi, David H Peng, B Leticia Rodriguez, Jiaqi Zhang, Veronica Zheng, Dzifa Y Duose, Luisa Maren Solis Soto, Barbara Mino, Maria Gabriela Raso, Carmen Behrens, Ignacio I Wistuba, Kenneth L Scott, Mark Smith, Khanh Nguyen, Grace Lam, Ingrid Choong, Abhijit Mazumdar, Jamal L Hill, Don L Gibbons, Powel H Brown, William K Russell, Kevan M Shokat, Chad J Creighton, Jeffrey S Glenn
PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma. Science translational medicine 12 (527) (2021)
Tia A Tummino, Veronica V Rezelj, Benoit Fischer, Audrey Fischer, Matthew J O'Meara, Blandine Monel, Thomas Vallet, Ziyang Zhang, Assaf Alon, Henry R O'Donnell, Jiankun Lyu, Heiko Schadt, Kris M White, Nevan J Krogan, Laszlo Urban, Kevan M Shokat, Andrew C Kruse, Adolfo García-Sastre, Olivier Schwartz, Francesca Moretti, Marco Vignuzzi, Francois Pognan, Brian K Shoichet
Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2. bioRxiv : the preprint server for biology (2021)
Kris M White, Romel Rosales, Soner Yildiz, Thomas Kehrer, Lisa Miorin, Elena Moreno, Sonia Jangra, Melissa B Uccellini, Raveen Rathnasinghe, Lynda Coughlan, Carles Martínez-Romero, Jyoti Batra, Ajda Rojc, Mehdi Bouhaddou, Jacqueline M Fabius, Kirsten Obernier, Marion Dejosez, María José Guillén, Alejandro Losada, Pablo Avilés, Michael Schotsaert, Thomas P Zwaka, Marco Vignuzzi, Kevan M Shokat, Nevan J Krogan, Adolfo García-Sastre
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A. Science (New York, N.Y.) 371 (6532) (2021)
Lucy G Thorne, Mehdi Bouhaddou, Ann-Kathrin Reuschl, Lorena Zuliani-Alvarez, Benjamin J Polacco, Adrian Pelin, Jyoti Batra, Matthew V X Whelan, Myra Hosmillo, Andrea Fossati, Roberta Ragazzini, Irwin Jungreis, Manisha Ummadi, Ajda Rojc, Jane Turner, Marie L Bischof, Kirsten Obernier, Hannes Braberg, Margaret Soucheray, Alicia Richards, Kuei-Ho Chen, Bhavya Harjai, Danish Memon, Joseph Hiatt, Romel Rosales, Briana Lynn McGovern, Aminu S Jahun, Jacqueline M Fabius, Kris M White, Ian G Goodfellow, Yasu Takeuchi, Paola Bonfanti, Kevan M Shokat, Natalia Jura, Kliment A Verba, Mahdad Noursadeghi, Pedro Beltrao, Manolis Kellis, Danielle L Swaney, Adolfo García-Sastre, Clare Jolly, Greg J Towers, Nevan J Krogan
Evolution of enhanced innate immune evasion by SARS-CoV-2. Nature 602 (7897) (2021)
Yann Ehinger, Ziyang Zhang, Khanhky Phamluong, Drishti Soneja, Kevan M Shokat, Dorit Ron
Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice. Nature communications 12 (1) (2021)
Lucy G Thorne, Mehdi Bouhaddou, Ann-Kathrin Reuschl, Lorena Zuliani-Alvarez, Benjamin J Polacco, Adrian Pelin, Jyoti Batra, Matthew V X Whelan, Manisha Ummadi, Ajda Rojc, Jane Turner, Kirsten Obernier, Hannes Braberg, Margaret Soucheray, Alicia L Richards, Kuei-Ho Chen, Bhavya Harjai, Danish Memon, Myra Hosmillo, Joseph Hiatt, Aminu S Jahun, Ian G Goodfellow, Jacqueline M Fabius, Kevan M Shokat, Natalia Jura, Kliment A Verba, Mahdad Noursadeghi, Pedro Beltrao, Danielle L Swaney, Adolfo García-Sastre, Clare Jolly, Greg J Towers, Nevan J Krogan
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant. bioRxiv : the preprint server for biology (2021)
Tia A Tummino, Veronica V Rezelj, Benoit Fischer, Audrey Fischer, Matthew J O'Meara, Blandine Monel, Thomas Vallet, Kris M White, Ziyang Zhang, Assaf Alon, Heiko Schadt, Henry R Oâ Donnell, Jiankun Lyu, Romel Rosales, Briana L McGovern, Raveen Rathnasinghe, Sonia Jangra, Michael Schotsaert, Jean-René Galarneau, Nevan J Krogan, Laszlo Urban, Kevan M Shokat, Andrew C Kruse, Adolfo García-Sastre, Olivier Schwartz, Francesca Moretti, Marco Vignuzzi, Francois Pognan, Brian K Shoichet
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. Science (New York, N.Y.) 373 (6554) (2021)
Adam J Wolpaw, Richard Bayliss, Gabriele Büchel, Chi Van Dang, Martin Eilers, W Clay Gustafson, Gwenn H Hansen, Natalia Jura, Stefan Knapp, Mark A Lemmon, David Levens, John M Maris, Ronen Marmorstein, Steven J Metallo, Julie R Park, Linda Z Penn, Michael Rape, Martine F Roussel, Kevan M Shokat, William P Tansey, Kliment A Verba, Seychelle M Vos, William A Weiss, Elmar Wolf, Yael P Mosse
Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers. Cancer research 81 (7) (2021)
Guang Yang, Deanne Francis, James R Krycer, Mark Larance, Ziyang Zhang, Kevan M Shokat, Alexis Díaz-Vegas, Kevan M Shokat, David E James
Dissecting the biology of mTORC1 beyond rapamycin. Science signaling 14 (701) (2021)
Keelan Z Guiley, Jack W Stevenson, Kevin Lou, Krister J Barkovich, Vishnu Kumarasamy, Tilini U Wijeratne, Katharine L Bunch, Sarvind M Tripathi, Erik S Knudsen, Agnieszka K Witkiewicz, Kevan M Shokat, Seth M Rubin
p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science (New York, N.Y.) 366 (6471) (2020)
David E Gordon, Gwendolyn M Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M White, Matthew J O'Meara, Veronica V Rezelj, Jeffrey Z Guo, Danielle L Swaney, Tia A Tummino, Ruth Hüttenhain, Robyn M Kaake, Alicia L Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J Polacco, Hannes Braberg, Jacqueline M Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J Bennett, Merve Cakir, Michael J McGregor, Qiongyu Li, Bjoern Meyer, Ferdinand Roesch, Thomas Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ying Shi, Ziyang Zhang, Wenqi Shen, Ilsa T Kirby, James E Melnyk, John S Chorba, Kevin Lou, Shizhong A Dai, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J P Mathy, Tina Perica, Kala Bharath Pilla, Sai J Ganesan, Daniel J Saltzberg, Ramachandran Rakesh, Xi Liu, Sara Brin Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, José M Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, YongFeng Liu, Stephanie A Wankowicz, Markus Bohn, Maliheh Safari, Fatima S Ugur, Cassandra Koh, Nastaran Sadat Savar, Quang Dinh Tran, Djoshkun Shengjuler, Sabrina J Fletcher, Michael C O'Neal, Yiming Cai, Jason C J Chang, David J Broadhurst, Saker Klippsten, Phillip P Sharp, Nicole A Wenzell, Duygu Kuzuoglu-Ozturk, Hao-Yuan Wang, Raphael Trenker, Janet M Young, Devin A Cavero, Joseph Hiatt, Theodore L Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Robert M Stroud, Alan D Frankel, Oren S Rosenberg, Kliment A Verba, David A Agard, Melanie Ott, Michael Emerman, Natalia Jura, Mark Von Zastrow, Eric Verdin, Alan Ashworth, Olivier Schwartz, Christophe D'Enfert, Shaeri Mukherjee, Matthew P Jacobson, Harmit Singh Malik, Danica G Fujimori, Trey Ideker, Charles S Craik, Stephen N Floor, Brian K Shoichet, John D Gross, Andrej Sali, Bryan L Roth, Davide Ruggero, Jack Taunton, Tanja Kortemme, Pedro Beltrao, Marco Vignuzzi, Adolfo García-Sastre, Kevan M Shokat, Brian K Shoichet, Nevan J Krogan
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583 (7816) (2020)
David E Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V Rezelj, Svenja Ulferts, Hannes Braberg, Alexander S Jureka, Kirsten Obernier, Jeffrey Z Guo, Jyoti Batra, Robyn M Kaake, Andrew R Weckstein, Tristan W Owens, Meghna Gupta, Sergei Pourmal, Erron W Titus, Merve Cakir, Margaret Soucheray, Michael J McGregor, Zeynep Cakir, Gwendolyn M Jang, Matthew J O'Meara, Tia A Tummino, Ziyang Zhang, Helene Foussard, Ajda Rojc, Yuan Zhou, Dmitry Kuchenov, Ruth Hüttenhain, Jiewei Xu, Manon Eckhardt, Danielle L Swaney, Jacqueline M Fabius, Manisha Ummadi, Beril Tutuncuoglu, Ujjwal Rathore, Maya Modak, Paige Haas, Kelsey M Haas, Zun Zar Chi Naing, Ernst H Pulido, Ying Shi, Inigo Barrio-Hernandez, Danish Memon, Eirini Petsalaki, Alistair S Dunham, Miguel Correa Marrero, David Francis Burke, Cassandra Koh, Thomas Vallet, Jesus A Silvas, Caleigh M Azumaya, Christian B Billesbølle, Axel F Brilot, Melody G Campbell, Amy Diallo, Miles Sasha Dickinson, Devan Diwanji, Nadia Herrera, Nicholas Hoppe, Huong T Kratochvil, Yanxin Liu, Gregory E Merz, Michelle Moritz, Henry C Nguyen, Carlos A Nowotny, Cristina Puchades, Alexandrea N Rizo, Ursula Schulze-Gahmen, Amber M Smith, Ming Sun, Iris D Young, Jianhua Zhao, Daniel Asarnow, Justin T Biel, Alisa Bowen, Julian R Braxton, Jen Chen, Cynthia M Chio, Un Seng Chio, Ishan Deshpande, Loan Doan, Bryan Faust, Sebastian Flores, Mingliang Jin, Sun Kyung Kim, Victor L Lam, Fei Li, Junrui Li, Grant J Jensen, Yang Li, Xi Liu, Megan Lo, Kyle E Lopez, Arthur A Melo, Frank R Moss, Phuong Nguyen, Joana Paulino, Komal Ishwar Pawar, Jessica K Peters, Thomas H Pospiech, Maliheh Safari, Smriti Sangwan, Kaitlin Schaefer, Paul V Thomas, Aye C Thwin, Raphael Trenker, Eric Tse, Tsz Kin Martin Tsui, Feng Wang, Natalie Whitis, Zanlin Yu, Kaihua Zhang, Sunny Zhang, Fengbo Zhou, Daniel J Saltzberg, null null, Anthony J Hodder, Amber S Shun-Shion, Daniel M Williams, Kris M White, Romel Rosales, Thomas Kehrer, Lisa Miorin, Elena Moreno, Arvind H Patel, Suzannah J Rihn, Mir Mubashir Khalid, Albert Vallejo-Gracia, Parinaz Fozouni, Camille R Simoneau, Theodore L Roth, David Wu, Mohd Anisul Karim, Maya Ghoussaini, Ian Dunham, Francesco Berardi, Sebastian Weigang, Maxime Chazal, Jisoo Park, James P Logue, Marisa E McGrath, Stuart M Weston, Robert E Haupt, C James Hastie, Matthew Elliott, Fiona Brown, Kerry A Burness, Elaine Reid, Mark Dorward, Clare Johnson, Stuart G Wilkinson, Anna Geyer, Daniel M Giesel, Carla Baillie, Samantha Raggett, Hannah Leech, Rachel Toth, Nicola Goodman, Kathleen C Keough, Abigail L Lind, null null, Reyna J Klesh, Kafi R Hemphill, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Travis Maures, Katherine S Pollard, Andrej Sali, David A Agard, Yifan Cheng, Brian K Shoichet, Adam Frost, Natalia Jura, Tanja Kortemme, Aashish Manglik, Daniel R Southworth, Robert M Stroud, Dario R Alessi, Paul Davies, Matthew B Friemann, Trey Ideker, Carmen Abate, Nolwenn Jouvenet, Georg Kochs, Brian K Shoichet, Melanie M Ott, Massimo Palmarini, Kevan M Shokat, Adolfo García-Sastre, Jeremy A Rassen, Robert Grosse, Oren S Rosenberg, Kliment A Verba, Christopher F Basler, Marco Vignuzzi, Andrew A Peden, Pedro Beltrao, Nevan J Krogan
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.) 370 (6521) (2020)
Kevin Lou, Veronica Steri, Alex Y Ge, Y Christina Hwang, Christopher H Yogodzinski, Arielle R Shkedi, Alex L M Choi, Dominique C Mitchell, Danielle L Swaney, Byron C Hann, John D Gordan, Kevan M Shokat, Luke A Gilbert
KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Science signaling 12 (583) (2019)
Yoko Katsuno, Dominique Stephan Meyer, Ziyang Zhang, Kevan M Shokat, Rosemary J Akhurst, Kohei Miyazono, Rik Derynck
Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Science signaling 12 (570) (2019)
Ziyang Zhang, Kevan M Shokat
Bifunctional Small-Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins. Angewandte Chemie (International ed. in English) 58 (45) (2019)
Kevin Lou, Luke A Gilbert, Kevan M Shokat
A Bounty of New Challenging Targets in Oncology for Chemical Discovery. Biochemistry 58 (31) (2019)
Robyn A Wong, Xujun Luo, Mimi Lu, Zhenyi An, Daphne A Haas-Kogan, Joanna J Phillips, Kevan M Shokat, William A Weiss, Qi Wen Fan
Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma. Cancer research 80 (4) (2019)
Chester E Chamberlain, Michael S German, Katherine Yang, Jason Wang, Henry VanBrocklin, Melanie Regan, Kevan M Shokat, Gregory S Ducker, Grace E Kim, Byron Hann, David B Donner, Robert S Warren, Alan P Venook, Emily K Bergsland, Danny Lee, Yucheng Wang, Eric K Nakakura
A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors. Molecular cancer therapeutics 17 (12) (2018)

Kevan M Shokat.css-eqlu8i{font-size:small;padding-left:4px;} (K Shokat, Kevan Shokat)

Publication Activity (10 Years)

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Kevan M Shokat (K Shokat, Kevan Shokat)