Synthesis of paenipeptin C' analogues employing solution-phase CLipPA chemistry.
Juliana T W TongIman KavianiniaScott A FergusonGregory M CookPaul W R HarrisMargaret A BrimblePublished in: Organic & biomolecular chemistry (2020)
We herein report the synthesis of analogues of the antimicrobial lipopeptide, paenipeptin C', by installing varying lipid moieties using thiol-ene CLipPA (Cysteine Lipidation on a Peptide or Amino Acid) chemistry. Biological evaluation against both Gram-negative and Gram-positive strains indicated that several analogues possessed potent broad-spectrum antimicrobial activity.