PD-1 Expression on Intratumoral Regulatory T Cells is Associated with Lack of Benefit from Anti-PD-1 Therapy in Metastatic Clear Cell Renal Cell Carcinoma Patients.
Thomas DenizeOpeyemi A JagedeSayed MatarNourhan El AhmarDestiny J WestEmily WaltonAseman Sheshdeh BagheriVarunika SavlaYasmin Nabil LaimonSaurabh GuptaSai Vikram VemulaDavid A BraunKelly P BurkePaul J CatalanoGordon J FreemanRobert J MotzerMichael B AtkinsDavid F McDermottArlene H SharpeToni K ChoueiriSabina SignorettiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
PD-1 expression on Tregs is associated with resistance to PD-1 blockade in mccRCC, suggesting that targeting Tregs may synergize with PD-1 inhibition. A model that integrates PD-1 expression on Tregs and CD8+TIM-3-LAG3- cells has higher predictive value.
Keyphrases
- regulatory t cells
- poor prognosis
- end stage renal disease
- induced apoptosis
- squamous cell carcinoma
- small cell lung cancer
- ejection fraction
- chronic kidney disease
- binding protein
- long non coding rna
- stem cells
- prognostic factors
- immune response
- cell cycle arrest
- drug delivery
- endoplasmic reticulum stress
- signaling pathway