Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies.
Yi LiangSujeeve JeganathanStefano MarastoniAdam SharpInes FigueiredoRichard MarcellusAmanda MawsonZvi ShalevAleksandra PesicJoan SweetHaiyang GuoDavid UehlingBora GurelAntje J NeebHousheng Hansen HeBruce MontgomeryMarianne KoritzinskySamantha Richelle OakesJohann S de BonoMartin GleaveAmina ZoubeidiBradly G WoutersAnthony M JoshuaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Our findings identify BCL-2 and IKKB dependencies in clinically relevant ENZ-resistant prostate cancer cells in vitro and in vivo, but indicate that IKKB upregulation appears to have greater relevance to the progression of human castrate-resistant prostate cancer.