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Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies.

Yi LiangSujeeve JeganathanStefano MarastoniAdam SharpInes FigueiredoRichard MarcellusAmanda MawsonZvi ShalevAleksandra PesicJoan SweetHaiyang GuoDavid UehlingBora GurelAntje J NeebHousheng Hansen HeBruce MontgomeryMarianne KoritzinskySamantha Richelle OakesJohann S de BonoMartin GleaveAmina ZoubeidiBradly G WoutersAnthony M Joshua
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Our findings identify BCL-2 and IKKB dependencies in clinically relevant ENZ-resistant prostate cancer cells in vitro and in vivo, but indicate that IKKB upregulation appears to have greater relevance to the progression of human castrate-resistant prostate cancer.
Keyphrases
  • prostate cancer
  • radical prostatectomy
  • endothelial cells
  • cell proliferation
  • poor prognosis
  • signaling pathway
  • pluripotent stem cells
  • long non coding rna