Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose: OpenSAFELY cohort study using linked electronic health records.
Elsie M F HorneWilliam J HulmeRuth H KeoghTom M PalmerElizabeth J WilliamsonEdward P K ParkerAmelia C A GreenVenexia M WalkerAlex J WalkerHelen J CurtisLouis FisherBrian MackennaRichard CrokerLisa E M HopcroftRobin Y ParkJon MasseyJessica MorleyAmir MehrkarSebastian C J BaconDavid EvansPeter InglesbyCaroline E MortonGeorge HickmanSimon DavyTom WardIain DillinghamAlex J WalkerMiguel A HernánJonathan A C SternePublished in: BMJ (Clinical research ed.) (2022)
The rate at which estimated vaccine effectiveness waned was consistent for covid-19 related hospital admission, covid-19 related death, and positive SARS-CoV-2 test and was similar across subgroups defined by age and clinical vulnerability. If sustained to outcomes of infection with the omicron variant and to booster vaccination, these findings will facilitate scheduling of booster vaccination.