Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer's disease (DEBBIE-AD): a prospective observational multicohort study protocol.
Beatriz E PadrelaAmnah MahrooMervin TeeMarkus H SnevePaulien MoyaertOliver Marcel GeierJoost P A KuijerSoetkin BeunWibeke NordhøyYufei David ZhuMareike A BuckDaniel C HoinkissSimon KonstandinJörn HuberJulia WiersingaRoos RikkenDiederick de LeeuwHåkon GrydelandLynette TippettErin E CawstonEsin Ozturk-IsikJennifer LinnMoritz BrandtBetty M TijmsElsmarieke M van de GiessenMajon MullerAnders FjellKristine WalhovdAtle BjørnerudLene PålhaugenPer SelnesPatricia ClementEric AchtenUdunna AnazodoFrederik BarkhofSaima HilalTormod FladbyKlaus EickelCatherine MorganDavid L ThomasJan PetrMatthias GüntherHenk-Jan Mm MutsaertsPublished in: BMJ open (2024)
Ethics approval was obtained for 10 cohorts, and is pending for 3 cohorts. The results of the main trial and each of the secondary endpoints will be submitted for publication in a peer-reviewed journal.
Keyphrases
- blood brain barrier
- study protocol
- randomized controlled trial
- clinical trial
- cerebral ischemia
- public health
- open label
- phase iii
- cognitive decline
- phase ii
- density functional theory
- cross sectional
- double blind
- machine learning
- drug administration
- mild cognitive impairment
- brain injury
- global health
- molecular dynamics