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The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni.

Kathrin K GeyerUmar H NiaziDavid DuvalCéline CosseauChad TomlinsonIain W ChalmersMartin T SwainDavid J CutressUtibe Bickham-WrightSabrina E MunshiChristoph GrunauTimothy P YoshinoKarl F Hoffmann
Published in: PLoS neglected tropical diseases (2017)
The presence of a functional DNA methylation machinery in B. glabrata as well as the modulation of these gene products in response to schistosome products, suggests a vital role for DNA methylation during snail development/oviposition and parasite interactions. Further deciphering the role of this epigenetic process during Biomphalaria/Schistosoma co-evolutionary biology may reveal key factors associated with disease transmission and, moreover, enable the discovery of novel lifecycle intervention strategies.
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