Integrated longitudinal analysis of adult grade 4 diffuse gliomas with long-term relapse interval revealed upregulation of TGF-β signaling in recurrent tumors.

Elham KashaniDésirée SchnidrigAli Hashemi GheinaniMartina Selina NinckPhilipp ZensTheoni MaragkouUlrich BaumgartnerPhilippe SchuchtGunnar RätschMark A RubinSabina BerezowskaCharlotte K Y NgErik Vassellanull null

Published in: Neuro-oncology (2022)

Our results suggest an important role of TGF-β signaling in recurrent gliomas. This may have clinical implication, since TGF-β inhibitors have entered clinical phase studies and may potentially be used in combination therapy to interfere with chemoradiation resistance. Recurrent gliomas show high incidence of early branching evolution. High tumor plasticity is confirmed at the level of microRNA and mRNA expression profiles.

Keyphrases

combination therapy
high grade
transforming growth factor
low grade
cell proliferation
squamous cell carcinoma
radiation therapy
cross sectional
binding protein
young adults
case control