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Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy.

Jiawei ZhaoMatthias ElgetiEvan S O'BrienCecília P SárAmal Ei DaibaniJie HengXiaoou SunTao CheWayne L HubbellBrian K KobilkaChunlai Chen
Published in: bioRxiv : the preprint server for biology (2023)
Ligand-dependent conformational dynamics of the μ-opioid receptor determine downstream signaling efficacy.
Keyphrases
  • chronic pain
  • pain management
  • molecular dynamics simulations
  • molecular dynamics
  • single molecule