Tao Che

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 58

Top Topics

Molecular Dynamics Simulations

Top Venues

Nature communications

The FEBS journal

Nature chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature 631 (8021) (2024)
Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature (2024)
Sarah M Bernhard, Jianming Han, Tao Che
GPCR-G protein selectivity revealed by structural pharmacology. The FEBS journal 291 (13) (2024)
Dongliang Lu, Anyuan He, Min Tan, Marguerite Mrad, Amal El Daibani, Donghua Hu, Xuejing Liu, Brian Kleiboeker, Tao Che, Fong-Fu Hsu, Monika Bambouskova, Clay F Semenkovich, Irfan J Lodhi
Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. Nature communications 15 (1) (2024)
Sarah M Bernhard, Jianming Han, Tao Che
GPCR-G protein selectivity revealed by structural pharmacology. The FEBS journal 291 (13) (2024)
Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature 629 (8011) (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature 631 (8021) (2024)
Sarah M Bernhard, Jianming Han, Tao Che
GPCR-G protein selectivity revealed by structural pharmacology. The FEBS journal 291 (13) (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature (2024)
Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature 629 (8011) (2024)
Tao Che, Balazs Varga, Sarah M Bernhard, Amal El Daibani, Saheem Zaidi, Jordy Homing Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina Nazarova, Alexa Kouvelis, Shainnel Eans, Elyssa B Margolis, Jonathan F Fay, Amynah Amir Ali Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar
Structure-Guided Design of Partial Agonists at an Opioid Receptor. Research square (2024)
Tao Che, Balazs Varga, Sarah M Bernhard, Amal El Daibani, Saheem Zaidi, Jordy Homing Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina Nazarova, Alexa Kouvelis, Shainnel Eans, Elyssa B Margolis, Jonathan F Fay, Amynah Amir Ali Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar
Structure-Guided Design of Partial Agonists at an Opioid Receptor. Research square (2024)
Tao Che, Balazs Varga, Sarah M Bernhard, Amal El Daibani, Saheem Zaidi, Jordy Homing Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina Nazarova, Alexa Kouvelis, Shainnel Eans, Elyssa B Margolis, Jonathan F Fay, Amynah Amir Ali Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar
Structure-Guided Design of Partial Agonists at an Opioid Receptor. Research square (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature (2024)
Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature 629 (8011) (2024)
Dongliang Lu, Anyuan He, Min Tan, Marguerite Mrad, Amal El Daibani, Donghua Hu, Xuejing Liu, Brian Kleiboeker, Tao Che, Fong-Fu Hsu, Monika Bambouskova, Clay F Semenkovich, Irfan J Lodhi
Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. Nature communications 15 (1) (2024)
Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature (2024)
Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature 629 (8011) (2024)
Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature 629 (8011) (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature 631 (8021) (2024)
Dongliang Lu, Anyuan He, Min Tan, Marguerite Mrad, Amal El Daibani, Donghua Hu, Xuejing Liu, Brian Kleiboeker, Tao Che, Fong-Fu Hsu, Monika Bambouskova, Clay F Semenkovich, Irfan J Lodhi
Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. Nature communications 15 (1) (2024)
Dongliang Lu, Anyuan He, Min Tan, Marguerite Mrad, Amal El Daibani, Donghua Hu, Xuejing Liu, Brian Kleiboeker, Tao Che, Fong-Fu Hsu, Monika Bambouskova, Clay F Semenkovich, Irfan J Lodhi
Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. Nature communications 15 (1) (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature 631 (8021) (2024)
Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy. bioRxiv : the preprint server for biology (2023)
Edin Muratspahić, Kristine Deibler, Jianming Han, Nataša Tomašević, Kirtikumar B Jadhav, Aina-Leonor Olivé-Marti, Nadine Hochrainer, Roland Hellinger, Johannes Koehbach, Jonathan F Fay, Mohammad Homaidur Rahman, Lamees Hegazy, Timothy W Craven, Balazs R Varga, Gaurav Bhardwaj, Kevin Appourchaux, Susruta Majumdar, Markus Muttenthaler, Parisa Hosseinzadeh, David J Craik, Mariana Spetea, Tao Che, Julien S Baker, Christian W Gruber
Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor. Nature communications 14 (1) (2023)
Sarah M Bernhard, Jianming Han, Tao Che
GPCR-G protein selectivity revealed by structural pharmacology. The FEBS journal (2023)
Sarah M Bernhard, Jianming Han, Tao Che
GPCR-G protein selectivity revealed by structural pharmacology. The FEBS journal (2023)
Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy. bioRxiv : the preprint server for biology (2023)
Bo Cai, Amal El Daibani, Yuntian Bai, Tao Che, Casey J Krusemark
Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells. JACS Au 3 (4) (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Sarah M Bernhard, Tao Che
Capturing receptor states with glue. Nature chemical biology (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen
Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy. bioRxiv : the preprint server for biology (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Bo Cai, Amal El Daibani, Yuntian Bai, Tao Che, Casey J Krusemark
Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells. JACS Au 3 (4) (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature (2023)
Sarah M Bernhard, Jianming Han, Tao Che
GPCR-G protein selectivity revealed by structural pharmacology. The FEBS journal (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Stefan Gahbauer, Chelsea DeLeon, João M Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B Billesbølle, Yong-Feng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A Fink, Ivan S Kondratov, Yurii S Moroz, John J Irwin, Allan I Basbaum, Bryan L Roth, Brian K Shoichet
Docking for EP4R antagonists active against inflammatory pain. Nature communications 14 (1) (2023)
Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Ligand and G-protein selectivity in the κ-opioid receptor. Nature 617 (7960) (2023)
Qianhui Qu, Weijiao Huang, Deniz Aydin, Joseph M Paggi, Alpay B Seven, Haoqing Wang, Soumen Chakraborty, Tao Che, Jeffrey F DiBerto, Michael J Robertson, Asuka Inoue, Carl-Mikael Suomivuori, Bryan L Roth, Susruta Majumdar, Ron O Dror, Brian K Kobilka, Georgios Skiniotis
Insights into distinct signaling profiles of the µOR activated by diverse agonists. Nature chemical biology (2022)
Abdelfattah Faouzi, Haoqing Wang, Saheem A Zaidi, Jeffrey F DiBerto, Tao Che, Qianhui Qu, Michael J Robertson, Manish K Madasu, Amal El Daibani, Balazs R Varga, Tiffany Zhang, Claudia Ruiz, Shan Liu, Jin Xu, Kevin Appourchaux, Samuel T Slocum, Shainnel O Eans, Michael D Cameron, Ream Al-Hasani, Ying Xian Pan, Bryan L Roth, Jay P McLaughlin, Georgios Skiniotis, Vsevolod Katritch, Brian K Kobilka, Susruta Majumdar
Structure-based design of bitopic ligands for the µ-opioid receptor. Nature (2022)
Amal El Daibani, Tao Che
Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain. Molecules (Basel, Switzerland) 27 (3) (2022)
Anat Levit Kaplan, Danielle N Confair, Kuglae Kim, Ximena Barros-Álvarez, Ramona M Rodriguiz, Ying Yang, Oh Sang Kweon, Tao Che, John D McCorvy, David N Kamber, James P Phelan, Luan Carvalho Martins, Vladimir M Pogorelov, Jeffrey F DiBerto, Samuel T Slocum, Xi-Ping Huang, Manish Kumar Jain, Michael J Robertson, Ouliana Panova, Alpay B Seven, Autumn Q Wetsel, William C Wetsel, John J Irwin, Georgios Skiniotis, Brian K Shoichet, Bryan L Roth, Jonathan A Ellman
Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity. Nature 610 (7932) (2022)
Michael J Robertson, Makaía M Papasergi-Scott, Feng He, Alpay B Seven, Justin G Meyerowitz, Ouliana Panova, Maria Claudia Peroto, Tao Che, Georgios Skiniotis
Structure determination of inactive-state GPCRs with a universal nanobody. Nature structural & molecular biology (2022)
Tao Che, Hemlata Dwivedi-Agnihotri, Arun K Shukla, Bryan L Roth
Biased ligands at opioid receptors: Current status and future directions. Science signaling 14 (677) (2021)
Soumen Chakraborty, Jeffrey F DiBerto, Abdelfattah Faouzi, Sarah M Bernhard, Anna M Gutridge, Steven Ramsey, Yuchen Zhou, Davide Provasi, Nitin Nuthikattu, Rahul Jilakara, Melissa N F Nelson, Wesley B Asher, Shainnel O Eans, Lisa L Wilson, Satyanarayana M Chintala, Marta Filizola, Richard M Van Rijn, Elyssa B Margolis, Bryan L Roth, Jay P McLaughlin, Tao Che, Dalibor Sames, Jonathan A Javitch, Susruta Majumdar
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. Journal of medicinal chemistry 64 (18) (2021)
Soumen Chakraborty, Rajendra Uprety, Amal E Daibani, Valerie L Rouzic, Amanda Hunkele, Kevin Appourchaux, Shainnel O Eans, Nitin Nuthikattu, Rahul Jilakara, Lisa Thammavong, Gavril W Pasternak, Ying-Xian Pan, Jay P McLaughlin, Tao Che, Susruta Majumdar
Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom. ACS chemical neuroscience 12 (14) (2021)
Yuchen Zhou, Steven Ramsey, Davide Provasi, Amal El Daibani, Kevin Appourchaux, Soumen Chakraborty, Abhijeet Kapoor, Tao Che, Susruta Majumdar, Marta Filizola
Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom's Alkaloids with Reported Antinociception In Vivo. Biochemistry 60 (18) (2020)
Reed M Stein, Hye Jin Kang, John D McCorvy, Grant C Glatfelter, Anthony J Jones, Tao Che, Samuel Slocum, Xi-Ping Huang, Olena Savych, Yurii S Moroz, Benjamin Stauch, Linda C Johansson, Vadim Cherezov, Terry Kenakin, John J Irwin, Brian K Shoichet, Bryan L Roth, Margarita L Dubocovich
Virtual discovery of melatonin receptor ligands to modulate circadian rhythms. Nature 579 (7800) (2020)
Tao Che, Justin G English, Brian E Krumm, Kuglae Kim, Els Pardon, Reid H J Olsen, Sheng Wang, Shicheng Zhang, Jeffrey F Diberto, Noah Sciaky, F Ivy Carroll, Jan Steyaert, Daniel Wacker, Bryan L Roth
Nanobody-enabled monitoring of kappa opioid receptor states. Nature communications 11 (1) (2020)
Tao Che
Advances in the Treatment of Chronic Pain by Targeting GPCRs. Biochemistry 60 (18) (2020)
Reid H J Olsen, Jeffrey F DiBerto, Justin G English, Alexis M Glaudin, Brian E Krumm, Samuel T Slocum, Tao Che, Ariana C Gavin, John D McCorvy, Bryan L Roth, Ryan T Strachan
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome. Nature chemical biology 16 (8) (2020)