The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture.
Yongting LuoJunjie LuoPeng AnYuanfei ZhaoWenting ZhaoZhou FangYi XiaLin ZhuTeng XuXu ZhangShuaishuai ZhouMingyan YangJiayao LiJunming ZhuYongmin LiuHaiyang LiMing GongYuyong LiuJie HanHuiyuan GuoHongjia ZhangWenjian JiangFazheng RenPublished in: European heart journal (2023)
This cross-sectional compendium of cellular atlas of human ascending aortas during AD progression provides previously unappreciated insights into a transcriptional programme permitting aortic degeneration, highlighting a translational proof of concept for an anti-remodelling intervention as an attractive strategy to manage temporal-specific AD by modulating the tumour necrosis factor-OXPHOS-AP-1 axis.
Keyphrases
- aortic dissection
- transcription factor
- cross sectional
- study protocol
- endothelial cells
- randomized controlled trial
- gene expression
- induced pluripotent stem cells
- single cell
- heat shock
- signaling pathway
- pluripotent stem cells
- nuclear factor
- heart failure
- binding protein
- amino acid
- protein protein
- clinical trial
- inflammatory response
- left ventricular