The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization.
Sarah Z HanifCheukMan Cherie AuIngrid TorregrozaSyeda Y JannathTabassum FabihaBhavneet BhinderMichael P WashburnDominic DevostShuchen LiuPriya BhardwajTodd EvansPradeep Kumar AnandRobert TarranSailesh PalikheOlivier ElementoLukas E DowJohn BlenisTerence E HébertKristy A BrownPublished in: bioRxiv : the preprint server for biology (2024)
We show that loss of the orphan G protein-coupled receptor GPR52 in human breast cell lines leads to increased cell clustering, hybrid/partial EMT, and increased tumor burden in zebrafish.