Phenolic Compounds of Propolis Alleviate Lipid Metabolism Disorder.
Lingjie KongYuhao ZhangZhouxu FengJie DongHongcheng ZhangPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
Lipid metabolism disorder is one of the significant risk factors for a multitude of human diseases and has become a serious threat to human health. The present study aimed to evaluate the effects of phenolics from poplar-type propolis on regulating lipid metabolism by using cell models of steatosis induced by palmitic acid (PA). Our study shows that phenolic esters have higher lipid-lowering activities than phenolic acids, especially for three caffeic acid esters, including caffeic acid phenethyl ester (CAPE), caffeic acid cinnamyl ester (CACE), and caffeic acid benzyl ester (CABE). Most notably, CACE presents prominent properties to prevent intracellular lipid accumulation and to amend extracellular adipokine secretion abnormalities. In addition, our results firstly reveal that CACE can alleviate lipid metabolism disorder through mediating protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6) signaling pathway-associated protein expression, suppressing endoplasmic reticulum (ER) stress, and activating peroxisome proliferator-activated receptors (PPARs) by distinct upregulation of PPARα and downregulation of PPARγ.
Keyphrases
- endoplasmic reticulum
- signaling pathway
- transcription factor
- fatty acid
- human health
- protein kinase
- insulin resistance
- risk assessment
- cell proliferation
- endothelial cells
- single cell
- stem cells
- south africa
- type diabetes
- metabolic syndrome
- climate change
- bone marrow
- mesenchymal stem cells
- endoplasmic reticulum stress
- oxidative stress
- genome wide
- dna binding
- poor prognosis
- cell therapy
- tyrosine kinase
- pluripotent stem cells