In vitro reactions of a cyanocobalamin-cisplatin conjugate with nucleoside monophosphates.
Giovanni VenturaCosima Damiana CalvanoIlario LositoAndrea ViolaValeria CinquepalmiTommaso R I CataldiPublished in: Rapid communications in mass spectrometry : RCM (2021)
In agreement with literature data relevant to the interaction between CP and NMPs, the most reactive nucleotides were AMP and GMP. The present RPLC/ESI-MS/MS approach is very promising for investigation of the reactions of CP conjugates with ribonucleotides not only in vitro but also in vivo.