Increasing research suggests a connection between gut microbiota and depressive disorders. Targeted changes to the intestinal flora may contribute to alleviating anxiety and depression. This study aimed to identify probiotics that could attenuate stress-induced abnormal behavior and explore potential mechanisms. The administration of LR.KY16 significantly reduced stress-induced abnormal behaviors and physiological dysfunction. The mechanism may be via regulating the structure of the intestinal microbiota in mice, increasing the abundance of Akkermansia muciniphila , prompting enterochromaffin cells to secrete 5-HTP in the gut, which enters the brain through the bloodstream and promotes the synthesis of 5-HT in the brain, and then activates brain-derived neurotrophic factor (BDNF)/tyrosine kinase receptor B (TrkB) through the 5-HT1A receptor. In addition, LR.KY16 also increased the expression of claudin-7, occludin, and zonula occludens-1 (ZO-1) in the colon, inhibited microglial M1 polarization, and inhibited systemic inflammation.
Keyphrases
- stress induced
- tyrosine kinase
- resting state
- epidermal growth factor receptor
- white matter
- induced apoptosis
- binding protein
- poor prognosis
- functional connectivity
- depressive symptoms
- inflammatory response
- cell cycle arrest
- high fat diet induced
- escherichia coli
- neuropathic pain
- endoplasmic reticulum stress
- antibiotic resistance genes
- sleep quality
- microbial community
- physical activity
- spinal cord
- skeletal muscle
- human health
- spinal cord injury
- wild type