Nutritional Lifestyle Intervention in Obese Pregnant Women, Including Lower Carbohydrate Intake, Is Associated With Increased Maternal Free Fatty Acids, 3-β-Hydroxybutyrate, and Fasting Glucose Concentrations: A Secondary Factorial Analysis of the European Multicenter, Randomized Controlled DALI Lifestyle Intervention Trial.
Jürgen HarreiterDavid SimmonsGernot DesoyeRosa CorcoyJuan M AdelantadoRoland DevliegerSander GaljaardPeter DammElisabeth R MathiesenDorte M JensenLise Lotte T AndersenFidelma DunneAnnunziata LapollaMaria G DalfraAlessandra BertolottoEwa Wender-OzegowskaAgnieszka ZawiejskaUrszula MantajDavid HillJudith G M JelsmaFrank J SnoekMichael LeutnerChristian LackingerChristof WordaDagmar Bancher-TodescaHubert ScharnaglMireille N M van PoppelAlexandra Kautzky-WillerPublished in: Diabetes care (2019)
HE intervention was associated with reduced GWG, higher FFAs, higher 3BHB, and higher fasting glucose at 24-28 weeks of gestation, suggesting induction of lipolysis. Increased FFA was negatively associated with carbohydrate intake and was also observed in cord blood. These findings support the hypothesis that maternal antenatal dietary restriction including carbohydrates is associated with increased FFA mobilization.
Keyphrases
- pregnant women
- blood glucose
- randomized controlled trial
- cord blood
- metabolic syndrome
- weight loss
- pregnancy outcomes
- phase iii
- adipose tissue
- double blind
- birth weight
- fatty acid
- physical activity
- insulin resistance
- cardiovascular disease
- gestational age
- study protocol
- phase ii
- clinical trial
- open label
- weight gain
- placebo controlled
- cross sectional
- skeletal muscle