NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes.
Anne Carine ØstvoldKirsten GrundtClaudia WiesePublished in: The Biochemical journal (2022)
The Nuclear Casein and Cyclin-dependent Kinase Substrate 1 (NUCKS1) protein is highly conserved in vertebrates, predominantly localized to the nucleus and one of the most heavily modified proteins in the human proteome. NUCKS1 expression is high in stem cells and the brain, developmentally regulated in mice and associated with several diverse malignancies in humans, including cancer, metabolic syndrome and Parkinson's disease. NUCKS1 function has been linked to modulating chromatin architecture and transcription, DNA repair and cell cycle regulation. In this review, we summarize and discuss the published information on NUCKS1 and highlight the questions that remain to be addressed to better understand the complex biology of this multifaceted protein.
Keyphrases
- cell cycle
- dna repair
- transcription factor
- dna damage
- stem cells
- metabolic syndrome
- cell proliferation
- gene expression
- endothelial cells
- binding protein
- amino acid
- poor prognosis
- protein protein
- genome wide
- dna damage response
- insulin resistance
- randomized controlled trial
- protein kinase
- squamous cell
- african american
- white matter
- induced pluripotent stem cells
- skeletal muscle
- small molecule
- cell therapy
- brain injury
- tyrosine kinase
- cerebral ischemia
- pluripotent stem cells
- wild type