A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer.

Jieun SonJaebong JangTyler S BeyettYoonji EumHeidi M Haikala Alyssa L VeranoMika LinJohn M HatcherNicholas P KwiatkowskiPınar Özden EserMichael J PoitrasStephen WangMan XuPrafulla C GokhaleMichael D CameronMichael J Eck Nathanael S Gray Pasi A Janne

Published in: Cancer research (2022)

This study describes unique mechanisms of action of a new mutant-selective HER2 kinase inhibitor that reduces both kinase activity and protein levels of HER2 in lung cancer.

Keyphrases

wild type
tyrosine kinase
binding protein
small molecule