Michael J Eck (Michael Eck)

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 23

Top Topics

Tyrosine Kinase

Cystic Fibrosis

Small Cell Lung Cancer

Top Venues

Communications chemistry

Nature communications

The Journal of biological chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem 19 (12) (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem 19 (12) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem 19 (12) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem 19 (12) (2024)
Eunyoung Park, Shaun Rawson, Anna M Schmoker, Byeong-Won Kim, Sehee Oh, Kangkang Song, Hyesung Jeon, Michael J Eck
Cryo-EM structure of a RAS/RAF recruitment complex. Nature communications 14 (1) (2023)
Eunyoung Park, Shaun Rawson, Anna M Schmoker, Byeong-Won Kim, Sehee Oh, Kangkang Song, Hyesung Jeon, Michael J Eck
Publisher Correction: Cryo-EM structure of a RAS/RAF recruitment complex. Nature communications 14 (1) (2023)
David E Heppner, Florian Wittlinger, Blessing Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin Pham, Ilse Schaeffner, Brandon T Oligny, Surbhi Chitnis, Tyler Beyett, Alexander Rasch, Brian Buckley, Daniel Urul, Tatiana Shaurova, Earl May, Erik Schaefer, Michael J Eck, Pamela Hershberger, Antti Poso, Stefan A Laufer
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Research square (2023)
Zachary J Hauseman, Michelle Fodor, Anxhela Dhembi, Jessica Viscomi, David Egli, Melusine Bleu, Stephanie Katz, Eunyoung Park, Dong Man Jang, Kathryn A Porter, Fabian Meili, Hongqiu Guo, Grainne Kerr, Sandra Mollé, Camilo Velez-Vega, Kim S Beyer, Giorgio Giacomo Galli, Saveur-Michel Maira, Travis Stams, Kirk Clark, Michael J Eck, Luca Tordella, Claudio R Thoma, Daniel A King
Structure of the MRAS-SHOC2-PP1C phosphatase complex. Nature 609 (7926) (2022)
Gonzalo L González-Del Pino, Kunhua Li, Eunyoung Park, Anna M Schmoker, Byung Hak Ha, Michael J Eck
Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proceedings of the National Academy of Sciences of the United States of America 118 (36) (2022)
Ciric To, Tyler S Beyett, Jaebong Jang, William W Feng, Magda Bahcall, Heidi M Haikala, Bo H Shin, David E Heppner, Jaimin K Rana, Brittaney A Leeper, Kara M Soroko, Michael J Poitras, Prafulla C Gokhale, Yoshihisa Kobayashi, Kamal Wahid, Kari J Kurppa, Thomas W Gero, Michael D Cameron, Atsuko Ogino, Mierzhati Mushajiang, Chunxiao Xu, Yanxi Zhang, David A Scott, Michael J Eck, Nathanael S Gray, Pasi A Janne
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. Nature cancer 3 (4) (2022)
Jieun Son, Jaebong Jang, Tyler S Beyett, Yoonji Eum, Heidi M Haikala, Alyssa L Verano, Mika Lin, John M Hatcher, Nicholas P Kwiatkowski, Pınar Özden Eser, Michael J Poitras, Stephen Wang, Man Xu, Prafulla C Gokhale, Michael D Cameron, Michael J Eck, Nathanael S Gray, Pasi A Janne
A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer. Cancer research 82 (8) (2022)
Hwan Bae, Thibault Viennet, Eunyoung Park, Nam Chu, Antonieta Salguero, Michael J Eck, Haribabu Arthanari, Philip A Cole
PH domain-mediated autoinhibition and oncogenic activation of Akt. eLife 11 (2022)
Tyler S Beyett, Ciric To, David E Heppner, Jaimin K Rana, Anna M Schmoker, Jaebong Jang, Dries J H De Clercq, Gabriel Gomez, David A Scott, Nathanael S Gray, Pasi A Janne, Michael J Eck
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nature communications 13 (1) (2022)
David E Heppner, Michael J Eck
A structural perspective on targeting the RTK/Ras/MAP kinase pathway in cancer. Protein science : a publication of the Protein Society 30 (8) (2021)
David E Heppner, Tyler S Beyett, Michael J Eck
A driving test for oncogenic mutations. The Journal of biological chemistry 294 (24) (2020)
Jia-Wei Hsu, Ming Bai, Kunhua Li, Jia-Shu Yang, Nam Chu, Philip A Cole, Michael J Eck, Jian Li, Victor W Hsu
The protein kinase Akt acts as a coat adaptor in endocytic recycling. Nature cell biology 22 (8) (2020)