Tyler S Beyett

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 32

Top Venues

Molecular pharmacology

ChemMedChem

Journal of medicinal chemistry

Communications chemistry

Harvard Medical School

Univeristy of Michigan (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Harvard Medical School Sep 05 2018

United States

Research Fellow :: Biological Chemistry and Molecular Pharmacology

Dana Farber Cancer Institute Sep 05 2018

United States

Research Fellow :: Cancer Biology

Education History

Univeristy of Michigan Sep 01 2013 - Aug 17 2018

United States

PHD :: Chemical Biology

Saginaw Valley State University Sep 01 2009 - Apr 15 2013

United States

BSC :: Chemistry

Publications

Justin J Kim, Ilse K Schaeffner, David E Heppner, Ciric To, Pasi A Jänne, Tyler S Beyett, Michael J Eck
A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology. Molecular pharmacology 105 (2) (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem 19 (12) (2024)
Justin J Kim, Ilse K Schaeffner, David E Heppner, Ciric To, Pasi A Jänne, Tyler S Beyett, Michael J Eck
A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology. Molecular pharmacology 105 (2) (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem 19 (12) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Zhengnian Li, Wen Chao Lu, Tyler S Beyett, Scott B Ficarro, Jie Jiang, Jason Tse, Audrey Yong-Ju Kim, Jarrod A Marto, Jianwei Che, Pasi A Jänne, Michael J Eck, Tinghu Zhang, Nathanael S Gray
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of medicinal chemistry 67 (4) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Justin J Kim, Ilse K Schaeffner, David E Heppner, Ciric To, Pasi A Jänne, Tyler S Beyett, Michael J Eck
A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology. Molecular pharmacology 105 (2) (2024)
Justin J Kim, Ilse K Schaeffner, David E Heppner, Ciric To, Pasi A Jänne, Tyler S Beyett, Michael J Eck
A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology. Molecular pharmacology 105 (2) (2024)
Zhengnian Li, Jie Jiang, Scott B Ficarro, Tyler S Beyett, Ciric To, Isidoro Tavares, Yingde Zhu, Jiaqi Li, Michael J Eck, Pasi A Jänne, Jarrod A Marto, Tinghu Zhang, Jianwei Che, Nathanael S Gray
Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality. ACS central science 10 (6) (2024)
Zhengnian Li, Wen Chao Lu, Tyler S Beyett, Scott B Ficarro, Jie Jiang, Jason Tse, Audrey Yong-Ju Kim, Jarrod A Marto, Jianwei Che, Pasi A Jänne, Michael J Eck, Tinghu Zhang, Nathanael S Gray
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of medicinal chemistry (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Justin J Kim, Ilse K Schaeffner, David E Heppner, Ciric To, Pasi A Jänne, Tyler S Beyett, Michael J Eck
A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology. Molecular pharmacology 105 (2) (2024)
Zhengnian Li, Wen Chao Lu, Tyler S Beyett, Scott B Ficarro, Jie Jiang, Jason Tse, Audrey Yong-Ju Kim, Jarrod A Marto, Jianwei Che, Pasi A Jänne, Michael J Eck, Tinghu Zhang, Nathanael S Gray
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of medicinal chemistry 67 (4) (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem 19 (12) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Zhengnian Li, Jie Jiang, Scott B Ficarro, Tyler S Beyett, Ciric To, Isidoro Tavares, Yingde Zhu, Jiaqi Li, Michael J Eck, Pasi A Jänne, Jarrod A Marto, Tinghu Zhang, Jianwei Che, Nathanael S Gray
Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality. ACS central science 10 (6) (2024)
Zhengnian Li, Wen Chao Lu, Tyler S Beyett, Scott B Ficarro, Jie Jiang, Jason Tse, Audrey Yong-Ju Kim, Jarrod A Marto, Jianwei Che, Pasi A Jänne, Michael J Eck, Tinghu Zhang, Nathanael S Gray
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of medicinal chemistry 67 (4) (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem (2024)
Tyler S Beyett, Jaimin K Rana, Ilse K Schaeffner, David E Heppner, Michael J Eck
Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. ChemMedChem 19 (12) (2024)
Justin J Kim, Ilse K Schaeffner, David E Heppner, Ciric To, Pasi A Jänne, Tyler S Beyett, Michael J Eck
A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology. Molecular pharmacology (2023)
Ciric To, Tyler S Beyett, Jaebong Jang, William W Feng, Magda Bahcall, Heidi M Haikala, Bo H Shin, David E Heppner, Jaimin K Rana, Brittaney A Leeper, Kara M Soroko, Michael J Poitras, Prafulla C Gokhale, Yoshihisa Kobayashi, Kamal Wahid, Kari J Kurppa, Thomas W Gero, Michael D Cameron, Atsuko Ogino, Mierzhati Mushajiang, Chunxiao Xu, Yanxi Zhang, David A Scott, Michael J Eck, Nathanael S Gray, Pasi A Janne
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. Nature cancer 3 (4) (2022)
Jieun Son, Jaebong Jang, Tyler S Beyett, Yoonji Eum, Heidi M Haikala, Alyssa L Verano, Mika Lin, John M Hatcher, Nicholas P Kwiatkowski, Pınar Özden Eser, Michael J Poitras, Stephen Wang, Man Xu, Prafulla C Gokhale, Michael D Cameron, Michael J Eck, Nathanael S Gray, Pasi A Janne
A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer. Cancer research 82 (8) (2022)
Tyler S Beyett, Ciric To, David E Heppner, Jaimin K Rana, Anna M Schmoker, Jaebong Jang, Dries J H De Clercq, Gabriel Gomez, David A Scott, Nathanael S Gray, Pasi A Janne, Michael J Eck
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nature communications 13 (1) (2022)
Jennifer A Amrhein, Tyler S Beyett, William W Feng, Andreas Krämer, Janik Weckesser, Ilse K Schaeffner, Jaimin K Rana, Pasi A Jänne, Michael J Eck, Stefan Knapp, Thomas Hanke
Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. Journal of medicinal chemistry 65 (23) (2022)
Florian Wittlinger, David E Heppner, Ciric To, Marcel Günther, Bo Hee Shin, Jaimin K Rana, Anna M Schmoker, Tyler S Beyett, Lena Marie Berger, Benedict-Tilmann Berger, Nicolas Bauer, James D Vasta, Cesear R Corona, Matthew B Robers, Stefan Knapp, Pasi A Jänne, Michael J Eck, Stefan A Laufer
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. Journal of medicinal chemistry (2021)
Ikuko Takeda Nakamura, Shinji Kohsaka, Masachika Ikegami, Hiroshi Ikeuchi, Toshihide Ueno, Kunhua Li, Tyler S Beyett, Takafumi Koyama, Toshio Shimizu, Noboru Yamamoto, Fumiyuki Takahashi, Kazuhisa Takahashi, Michael J Eck, Hiroyuki Mano
Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer. NPJ precision oncology 5 (1) (2021)
David E Heppner, Tyler S Beyett, Michael J Eck
A driving test for oncogenic mutations. The Journal of biological chemistry 294 (24) (2020)
Tyler S Beyett, Amy E Fraley, Emily Labudde, Dhabaleswar Patra, Ryan C Coleman, Akito Eguchi, Alisa Glukhova, Qiuyan Chen, Robert M Williams, Walter J Koch, David H Sherman, John Joseph Grubb Tesmer
Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proceedings of the National Academy of Sciences of the United States of America 116 (32) (2019)
Tyler S Beyett, Xinmin Gan, Shannon M Reilly, Louise Chang, Andrew V Gomez, Alan R Saltiel, Hollis D Showalter, John J G Tesmer
Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition. Molecular pharmacology 94 (4) (2018)

Tyler S Beyett.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

Tyler S Beyett