Anti-Inflammatory, Antioxidant, and Neuroprotective Effects of Polyphenols-Polyphenols as an Element of Diet Therapy in Depressive Disorders.
Anna Winiarska-MieczanMałgorzata KwiecieńKarolina Jachimowicz-RogowskaJanine DonaldsonEwa TomaszewskaEwa Baranowska-WójcikPublished in: International journal of molecular sciences (2023)
Depressive disorders can affect up to 350 million people worldwide, and in developed countries, the percentage of patients with depressive disorders may be as high as 10%. During depression, activation of pro-inflammatory pathways, mitochondrial dysfunction, increased markers of oxidative stress, and a reduction in the antioxidant effectiveness of the body are observed. It is estimated that approximately 30% of depressed patients do not respond to traditional pharmacological treatments. However, more and more attention is being paid to the influence of active ingredients in food on the course and risk of neurological disorders, including depression. The possibility of using foods containing polyphenols as an element of diet therapy in depression was analyzed in the review. The possibility of whether the consumption of products such as polyphenols could alleviate the course of depression or prevent the progression of it was also considered. Results from preclinical studies demonstrate the potential of phenolic compounds have the potential to reduce depressive behaviors by regulating factors related to oxidative stress, neuroinflammation, and modulation of the intestinal microbiota.
Keyphrases
- oxidative stress
- anti inflammatory
- depressive symptoms
- bipolar disorder
- sleep quality
- stress induced
- physical activity
- randomized controlled trial
- weight loss
- dna damage
- systematic review
- end stage renal disease
- traumatic brain injury
- ejection fraction
- human health
- induced apoptosis
- risk assessment
- diabetic rats
- lipopolysaccharide induced
- stem cells
- signaling pathway
- working memory
- mesenchymal stem cells
- bone marrow
- heat shock protein
- patient reported outcomes
- cerebral ischemia
- patient reported
- subarachnoid hemorrhage