Baseline brain function in the preadolescents of the ABCD Study.

Bader ChaaraniS HahnNicholas AllgaierS AdiseM M OwensA C JulianoD K YuanH LosoA IvanciuM D AlbaughJ DumasScott MackeyJ LaurentM IvanovaD J HaglerM D CornejoSean N Hatton Arpana AgrawalL AguinaldoL AhonenW AklinA P AnokhinJ ArroyoS AvenevoliD BabcockK BagotF C BakerM T BanichDeanna M BarchH BartschArielle R Baskin-SommersJ M BjorkD Blachman-DemnerM BlochR BogdanS Y BookheimerFlorence J Breslin Sandra A BrownF J CalabroV CalhounB J CaseyLinda ChangD B ClarkChristine C Cloak R xsTodd ConstableK ConstableR CorleyL B CottlerStefany J CoxeR K DagherAnders M DaleM DaprettoR Delcarmen-WigginsAnthony Steven DickE K DoN U F DosenbachG J DowlingSarah M EdwardsT M ErnstDamien A Fair Chun-Chieh FanE FeczkoS W Feldstein-EwingP FlorsheimJohn J Foxe Edward G FreedmanN P FriedmanS Friedman-HillBernard F FuemmelerA GalvanDylan G GeeJ GieddM GlantzP GlaserJ GodinoM GonzalezR GonzalezS GrantK M GrayF Haist Michael P HarmsS HawesA C HeathS HeeringaM M HeitzegR HermosilloM M HertingJ M HettemaJ K HewittC HeyserE HoffmanK HowlettR S HuberM A HuestisLuke W HydeW G IaconoM A InfanteO IrfanogluAmal IsaiahS IyengarJ JacobusR JamesB Jean-FrancoisTerry L JerniganN R KarcherA KaufmanB KelleyB KitA KsinanJ KupermanAngela R LairdC LarsonKimberly H LeBlancC Lessov-SchlaggerN LeverDavid A LewisK LisdahlA R LittleM LopezM LucianaB LunaP A MaddenH H MaesC MakowskiAndrew T MarshallM J MasonJ MatochikB D McCandlissE McGladeI MontoyaG MorganA MorrisC MulfordP MurrayB J NagelM C NealeG NeighA NenckaA NoronhaS J NixonC E PalmerV PariyadathMartin P PaulusW E PelhamD PfefferbaumC PierpaoliA PrescotDevin ProutyL I PuttlerN RajapaskeK M RapuanoG ReevesP F RenshawMichael C RiedelP RojasM de la RosaMonica D RosenbergM J RossM SanchezClaudiu SchirdaD SchloesserJ SchulenbergK J SherC ShethPaul D ShillingW K SimmonsElizabeth R SowellN SpeerM SpittelLindsay M Squeglia Chandra SripadaJ SteinbergC StrileyM T SutherlandJody TanabeS F TapertW ThompsonR L TomkoK A UbanScott I VriezeN E WadeRichard WattsS WeissB A WiensO D WilliamsA WilburD WingD Wolff-HughesR YangD A Yurgelun-ToddR A ZuckerA PotterHugh Garavannull null

Published in: Nature neuroscience (2021)

The Adolescent Brain Cognitive Development (ABCD) Study® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N = 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N = 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development.

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