Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program.
Jovanka Gencel-AugustoXiaoping SuYuan QiElizabeth M WhitleyVinod PantShunbin XiongVrutant V ShahJerome LinEncarnacion PerezMarta L FiorottoIqbal MahmudAbhinav K JainPhilip L LorenziNicholas E NavinEllen R RichieGuillermina LozanoPublished in: Cancer discovery (2023)
New mouse models with TP53R342P (monomer) or TP53A347D (dimer) mutations mimic Li-Fraumeni syndrome. Although p53 monomers lack function, p53 dimers conferred noncanonical tumor-suppressive activities. We describe novel activities for p53 dimers facilitated by PPARs and propose these are "basal" p53 activities.