Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopathy.
Edgar E NolletMaike SchuldtVasco SequeiraAleksandra BinekThang V PhamStephan A C SchoonveldeMark JansenBauke V SchomakersMichel van WeeghelFrederic M VazRiekelt H L HoutkooperJennifer E Van EykConnie R JiménezMichelle MichelsKenneth C BediKenneth B MarguliesCristobal G Dos RemediosDiederik W D KusterJolanda van der VeldenPublished in: Circulation. Genomic and precision medicine (2024)
We provide novel insights into both general and genotype-specific metabolic changes in HCM. Distinct metabolic alterations underlie cardiac disease progression in genotype-negative and genotype-positive patients with HCM.