Alcohol misuse, one of today's greatest public health challenges, is a developmentally dynamic, complex behavior at the intersection of genetic and environmental influences. This review examines such influences from a behavior genetics perspective and discusses implications for public policy. Alcohol misuse is moderately heritable with genetic influences accounting for around 50% of its variance, but to date few specific genes have been identified. However, numerous environmental and social factors moderate genetic risk, including parents, peers, romantic partners, family dynamics, employment, laws, and cultural influences. These moderating factors change in salience across development, and, accordingly, no one-size-fits-all approach is suitable for reducing alcohol misuse at a large scale. We provide examples of some effective prevention and intervention programs and discuss a framework for using the behavior genetics evidence to inform future public policy efforts.
Keyphrases
- public health
- healthcare
- chronic pain
- mental health
- genome wide
- alcohol consumption
- randomized controlled trial
- copy number
- emergency department
- human health
- dna methylation
- global health
- risk assessment
- quality improvement
- high intensity
- social support
- gene expression
- climate change
- functional connectivity
- hiv infected
- men who have sex with men
- antiretroviral therapy