Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures.
Wenrui GuoLinsey M PorterThomas Wm CrozierMatthew CoatesAkhilesh JhaMikel McKieJames A NathanPaul J LehnerEdward J D GreenwoodFrank McCaughanPublished in: Life science alliance (2022)
These experiments demonstrate a potential therapeutic role for topical camostat for pre- or post-exposure prophylaxis of SARS-CoV-2, which can now be evaluated in a clinical trial.