James A Nathan

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 46

Top Venues

The EMBO journal

PLoS biology

Nature immunology

Nature communications

University of Cambridge

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge

United Kingdom

Wellcome Senior Clnical Research Fellow, Honorary Consultant Physician :: Medicine

Publications

Aimee L Hanson, Matthew P Mulè, Hélène Ruffieux, Frederica Mescia, Laura Bergamaschi, Victoria S Pelly, Lorinda Turner, Prasanti Kotagiri, null null, Berthold Göttgens, Christoph Hess, Nicholas Gleadall, John R Bradley, James A Nathan, Paul A Lyons, Alexander Drakesmith, Kenneth G C Smith
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19. Nature immunology 25 (3) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal 43 (11) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal (2024)
Anna S Dickson, Tekle Pauzaite, Esther Arnaiz, Brian M Ortmann, James A West, Norbert Volkmar, Anthony W Martinelli, Zhaoqi Li, Niek Wit, Dennis Vitkup, Arthur Kaser, Paul J Lehner, James A Nathan
Author Correction: A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis. Nature communications 15 (1) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal (2024)
Aimee L Hanson, Matthew P Mulè, Hélène Ruffieux, Frederica Mescia, Laura Bergamaschi, Victoria S Pelly, Lorinda Turner, Prasanti Kotagiri, null null, Berthold Göttgens, Christoph Hess, Nicholas Gleadall, John R Bradley, James A Nathan, Paul A Lyons, Alexander Drakesmith, Kenneth G C Smith
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19. Nature immunology 25 (3) (2024)
Aimee L Hanson, Matthew P Mulè, Hélène Ruffieux, Frederica Mescia, Laura Bergamaschi, Victoria S Pelly, Lorinda Turner, Prasanti Kotagiri, null null, Berthold Göttgens, Christoph Hess, Nicholas Gleadall, John R Bradley, James A Nathan, Paul A Lyons, Alexander Drakesmith, Kenneth G C Smith
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19. Nature immunology 25 (3) (2024)
Tekle Pauzaite, Niek Wit, Rachel V Seear, James A Nathan
Deubiquitinating enzyme mutagenesis screens identify a USP43-dependent HIF-1 transcriptional response. The EMBO journal (2024)
Aimee L Hanson, Matthew P Mulè, Hélène Ruffieux, Frederica Mescia, Laura Bergamaschi, Victoria S Pelly, Lorinda Turner, Prasanti Kotagiri, null null, Berthold Göttgens, Christoph Hess, Nicholas Gleadall, John R Bradley, James A Nathan, Paul A Lyons, Alexander Drakesmith, Kenneth G C Smith
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19. Nature immunology 25 (3) (2024)
Anna S Dickson, Tekle Pauzaite, Esther Arnaiz, Brian M Ortmann, James A West, Norbert Volkmar, Anthony W Martinelli, Zhaoqi Li, Niek Wit, Dennis Vitkup, Arthur Kaser, Paul J Lehner, James A Nathan
Author Correction: A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis. Nature communications 15 (1) (2024)
Aimee L Hanson, Matthew P Mulè, Hélène Ruffieux, Frederica Mescia, Laura Bergamaschi, Victoria S Pelly, Lorinda Turner, Prasanti Kotagiri, null null, Berthold Göttgens, Christoph Hess, Nicholas Gleadall, John R Bradley, James A Nathan, Paul A Lyons, Alexander Drakesmith, Kenneth G C Smith
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19. Nature immunology 25 (3) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal (2024)
James A C Bertlin, Tekle Pauzaite, Qian Liang, Niek Wit, James C Williamson, Jia Jhing Sia, Nicholas J Matheson, Brian M Ortmann, Thomas J Mitchell, Anneliese O Speak, Qing Zhang, James A Nathan
VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING. bioRxiv : the preprint server for biology (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal 43 (11) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal 43 (11) (2024)
Aimee L Hanson, Matthew P Mulè, Hélène Ruffieux, Frederica Mescia, Laura Bergamaschi, Victoria S Pelly, Lorinda Turner, Prasanti Kotagiri, null null, Berthold Göttgens, Christoph Hess, Nicholas Gleadall, John R Bradley, James A Nathan, Paul A Lyons, Alexander Drakesmith, Kenneth G C Smith
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19. Nature immunology 25 (3) (2024)
Joycelyn Tan, Samuel Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Guillaume Bidault, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R Krycer, Richard J Mills, Lu Liang, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry Jm Baird, James A Horscroft, Alice P Sowton, Marcella K Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James A Nathan, James E Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley
Author Correction: Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. The EMBO journal (2024)
Jarrod Shilts, Thomas W M Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J D Greenwood, Samuel James Watson, Brian M Ortmann, Christian M Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A Nathan, Stefan H Pöhlmann, Nicholas J Matheson, Paul J Lehner, Gavin J Wright
LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein. PLoS biology 21 (2) (2023)
Jarrod Shilts, Thomas W M Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J D Greenwood, Samuel James Watson, Brian M Ortmann, Christian M Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A Nathan, Stefan H Pöhlmann, Nicholas J Matheson, Paul J Lehner, Gavin J Wright
LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein. PLoS biology 21 (2) (2023)
Jarrod Shilts, Thomas W M Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J D Greenwood, Samuel James Watson, Brian M Ortmann, Christian M Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A Nathan, Stefan H Pöhlmann, Nicholas J Matheson, Paul J Lehner, Gavin J Wright
LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein. PLoS biology 21 (2) (2023)
Anna S Dickson, Tekle Pauzaite, Esther Arnaiz, Brian M Ortmann, James A West, Norbert Volkmar, Anthony W Martinelli, Zhaoqi Li, Niek Wit, Dennis Vitkup, Arthur Kaser, Paul J Lehner, James A Nathan
Author Correction: A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis. Nature communications 14 (1) (2023)
Niek Wit, Ewa Gogola, James A West, Tristan Vornbäumen, Rachel V Seear, Peter S J Bailey, Guillermo Burgos-Barragan, Meng Wang, Patrycja A Krawczyk, Daphne H E W Huberts, Fanni Gergely, Nicholas J Matheson, Arthur Kaser, James A Nathan, Ketan J Patel
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production. Science advances 9 (20) (2023)
Niek Wit, Ewa Gogola, James A West, Tristan Vornbäumen, Rachel V Seear, Peter S J Bailey, Guillermo Burgos-Barragan, Meng Wang, Patrycja A Krawczyk, Daphne H E W Huberts, Fanni Gergely, Nicholas J Matheson, Arthur Kaser, James A Nathan, Ketan J Patel
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production. Science advances 9 (20) (2023)
Jarrod Shilts, Thomas W M Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J D Greenwood, Samuel James Watson, Brian M Ortmann, Christian M Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A Nathan, Stefan H Pöhlmann, Nicholas J Matheson, Paul J Lehner, Gavin J Wright
LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein. PLoS biology 21 (2) (2023)
Anna S Dickson, Tekle Pauzaite, Esther Arnaiz, Brian M Ortmann, James A West, Norbert Volkmar, Anthony W Martinelli, Zhaoqi Li, Niek Wit, Dennis Vitkup, Arthur Kaser, Paul J Lehner, James A Nathan
A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis. Nature communications 14 (1) (2023)
Niek Wit, Ewa Gogola, James A West, Tristan Vornbäumen, Rachel V Seear, Peter S J Bailey, Guillermo Burgos-Barragan, Meng Wang, Patrycja A Krawczyk, Daphne H E W Huberts, Fanni Gergely, Nicholas J Matheson, Arthur Kaser, James A Nathan, Ketan J Patel
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production. Science advances 9 (20) (2023)
Jarrod Shilts, Thomas W M Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J D Greenwood, Samuel James Watson, Brian M Ortmann, Christian M Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A Nathan, Stefan H Pöhlmann, Nicholas J Matheson, Paul J Lehner, Gavin J Wright
LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein. PLoS biology 21 (2) (2023)
Jarrod Shilts, Thomas W M Crozier, Ana Teixeira-Silva, Ildar Gabaev, Pehuén Pereyra Gerber, Edward J D Greenwood, Samuel James Watson, Brian M Ortmann, Christian M Gawden-Bone, Tekle Pauzaite, Markus Hoffmann, James A Nathan, Stefan H Pöhlmann, Nicholas J Matheson, Paul J Lehner, Gavin J Wright
LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein. PLoS biology 21 (2) (2023)
Eleanor Minogue, Pedro P Cunha, Brennan J Wadsworth, Guinevere L Grice, Shiv K Sah-Teli, Rob Hughes, David Bargiela, Alessandro Quaranta, Javier Zurita, Robin Antrobus, Pedro Velica, Laura Barbieri, Craig E Wheelock, Peppi Koivunen, James A Nathan, Iosifina Petrina Foskolou, Randall S Johnson
Glutarate regulates T cell metabolism and anti-tumour immunity. Nature metabolism (2023)
Thomas W M Crozier, Edward J D Greenwood, James C Williamson, Wenrui Guo, Linsey M Porter, Ildar Gabaev, Ana Teixeira-Silva, Guinevere L Grice, Arthur Wickenhagen, Richard James Stanton, Eddie C Y Wang, Sam J Wilson, Nicholas J Matheson, James A Nathan, Frank McCaughan, Paul J Lehner
Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion. Wellcome open research 7 (2022)
Wenrui Guo, Linsey M Porter, Thomas Wm Crozier, Matthew Coates, Akhilesh Jha, Mikel McKie, James A Nathan, Paul J Lehner, Edward J D Greenwood, Frank McCaughan
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures. Life science alliance 5 (4) (2022)
James A Nathan
Nitrosylation rewires metabolism. Nature chemical biology (2022)
James A Nathan
Chromatin oxygen sensing by histone H3 prolyl hydroxylation. Nature genetics 54 (11) (2022)
Brian M Ortmann, Natalie Burrows, Ian T Lobb, Esther Arnaiz, Niek Wit, Peter S J Bailey, Louise H Jordon, Olivia Lombardi, Ana Peñalver, James McCaffrey, Rachel Seear, David R Mole, Peter J Ratcliffe, Patrick H Maxwell, James A Nathan
The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes. Nature genetics 53 (7) (2021)
Brian M Ortmann, James A Nathan
Genetic approaches to understand cellular responses to oxygen availability. The FEBS journal (2021)
Peter S J Bailey, Brian M Ortmann, Anthony W Martinelli, Jack William Houghton, Ana S H Costa, Stephen P Burr, Robin Antrobus, Christian Frezza, James A Nathan
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex. Nature communications 11 (1) (2020)
Xiaoli Xiong, Kun Qu, Katarzyna A Ciazynska, Myra Hosmillo, Andrew P Carter, Soraya Ebrahimi, Zunlong Ke, Sjors H W Scheres, Laura Bergamaschi, Guinevere L Grice, Ying Zhang, null null, James A Nathan, Stephen Baker, Leo C James, Helen E Baxendale, Ian Goodfellow, Rainer Doffinger, John A G Briggs
A thermostable, closed SARS-CoV-2 spike protein trimer. Nature structural & molecular biology 27 (10) (2020)
James A Nathan
Squalene and cholesterol in the balance at the ER membrane. Proceedings of the National Academy of Sciences of the United States of America 117 (15) (2020)
Alba Signes, Raffaele Cerutti, Anna S Dickson, Cristiane Benincá, Elizabeth C Hinchy, Daniele Ghezzi, Rosalba Carrozzo, Enrico Silvio Bertini, Michael P Murphy, James A Nathan, Carlos Pardo-Hernández, Erika Fernández-Vizarra, Massimo Zeviani
APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS. EMBO molecular medicine 11 (1) (2019)
Sandra Stefanovic-Barrett, Anna S Dickson, Stephen P Burr, James C Williamson, Ian T Lobb, Dick Jh van den Boomen, Paul J Lehner, James A Nathan
MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins. EMBO reports 19 (5) (2018)
Peter S J Bailey, James A Nathan
Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron. Biomedicines 6 (2) (2018)
Sam A Menzies, Norbert Volkmar, Dick Jh van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1. eLife 7 (2018)
Peter S J Bailey, J Kalervo Hiltunen, Carol L Dieckmann, Alexander J Kastaniotis, James A Nathan
Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation. Proceedings of the National Academy of Sciences of the United States of America 115 (32) (2018)
Anna L Miles, Stephen P Burr, Guinevere L Grice, James A Nathan
The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels. eLife 6 (2017)
David C Thomas, Simon Clare, John M Sowerby, Mercedes Calvo Pardo, Jatinder K Juss, David A Goulding, Louise van der Weyden, Daniel M L Storisteanu, Ananth Prakash, Marion Espéli, Shaun M Flint, James C Lee, Kim Hoenderdos, Leanne Kane, Katherine Harcourt, Subhankar Mukhopadhyay, Yagnesh Umrania, Robin Antrobus, James A Nathan, David J Adams, Alex Bateman, Jyoti Sharma Choudhary, Paul A Lyons, Alison M Condliffe, Edwin R Chilvers, Gordon Dougan, Kenneth G C Smith
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. The Journal of experimental medicine 214 (4) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

James A Nathan