De novo missense variants disrupting protein-protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types.
Siwei ChenJiebiao WangA Ercument CicekKathryn RoederHaiyuan YuBernie DevlinPublished in: Molecular autism (2020)
Disrupted protein interactions identify gene sets involved in risk for ASD. Their gene expression during brain development and within cell types highlights how they relate to ASD.
Keyphrases
- autism spectrum disorder
- intellectual disability
- gene expression
- copy number
- single cell
- cell therapy
- genome wide
- poor prognosis
- attention deficit hyperactivity disorder
- binding protein
- dna methylation
- resting state
- stem cells
- amino acid
- genome wide identification
- multiple sclerosis
- functional connectivity
- long non coding rna
- small molecule