SGC-CAMKK2-1: A Chemical Probe for CAMKK2.
Carrow I WellsYi LiangThomas L PulliamChenchu LinDominik AwadBenjamin EdufulSean N O'ByrneMohammad Anwar HossainCarolina Moura Costa Catta-PretaPriscila Zonzini RamosOpher GileadiCarina GileadiRafael Miguez CouñagoBrittany StorkChristopher G LangendorfKevin NayJonathan S OakhillDebarati MukherjeeLuigi RacioppiAnthony R MeansBrian YorkDonald P McDonnellJohn W ScottDaniel E FrigoDavid Harold DrewryPublished in: Cells (2023)
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.