Rafael Miguez Couñago (R M Couñago, Rafael M Couñago)

ResearcherID ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 22

Top Topics

Plasmodium Falciparum

Tyrosine Kinase

Top Venues

Journal of medicinal chemistry

PLoS neglected tropical diseases

Scientific reports

This page only lists publications with an associated author ORCID identifier.

Publications

Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Fernando H de Souza Gama, Luiz A Dutra, Michael Hawgood, Caio Vinícius Dos Reis, Ricardo A M Serafim, Marcos A Ferreira, Bruno V M Teodoro, Jéssica Emi Takarada, André da Silva Santiago, Dimitrios-Ilias Balourdas, Ann-Sofie Nilsson, Bruno Urien, Vitor M Almeida, Carina Gileadi, Priscila Z Ramos, Anita Salmazo, Stanley N S Vasconcelos, Micael Rodrigues Cunha, Susanne Müller, Stefan Knapp, Katlin Brauer Massirer, Jonathan M Elkins, Opher Gileadi, Alessandra Mascarello, Bennie B L G Lemmens, Cristiano R W Guimarães, Hatylas Azevedo, Rafael Miguez Couñago
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε. Journal of medicinal chemistry 67 (11) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J Dickmander, Tammy M Havener, Marcia K Sanders, Jason W Brown, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2. Molecules (Basel, Switzerland) 29 (17) (2024)
Micael Rodrigues Cunha, Bruno S DO Amaral, Jéssica E Takarada, Gabriel V Valderrama, Andrea N L Batista, João Marcos Batista, Quezia B Cass, Rafael Miguez Couñago, Katlin Brauer Massirer
(S)-ML-SA1 Activates Autophagy via TRPML1-TFEB Pathway. Chembiochem : a European journal of chemical biology (2024)
Fernando H de Souza Gama, Luiz A Dutra, Michael Hawgood, Caio Vinícius Dos Reis, Ricardo A M Serafim, Marcos A Ferreira, Bruno V M Teodoro, Jéssica Emi Takarada, André da Silva Santiago, Dimitrios-Ilias Balourdas, Ann-Sofie Nilsson, Bruno Urien, Vitor M Almeida, Carina Gileadi, Priscila Z Ramos, Anita Salmazo, Stanley N S Vasconcelos, Micael Rodrigues Cunha, Susanne Müller, Stefan Knapp, Katlin Brauer Massirer, Jonathan M Elkins, Opher Gileadi, Alessandra Mascarello, Bennie B L G Lemmens, Cristiano R W Guimarães, Hatylas Azevedo, Rafael Miguez Couñago
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε. Journal of medicinal chemistry (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry (2024)
Carrow I Wells, Yi Liang, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean N O'Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael Miguez Couñago, Brittany Stork, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R Means, Brian York, Donald P McDonnell, John W Scott, Daniel E Frigo, David Harold Drewry
SGC-CAMKK2-1: A Chemical Probe for CAMKK2. Cells 12 (2) (2023)
Carrow I Wells, Yi Liang, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean N O'Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael Miguez Couñago, Brittany Stork, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R Means, Brian York, Donald P McDonnell, John W Scott, Daniel E Frigo, David Harold Drewry
SGC-CAMKK2-1: A Chemical Probe for CAMKK2. Cells 12 (2) (2023)
Matheus A Meirelles, Ian de Toledo, Samuel Thurow, Gabriela Barreiro, Rafael Miguez Couñago, Ronaldo Aloise Pilli
Functionalization of 2,4-Dichloropyrimidines by 2,2,6,6-Tetramethylpiperidyl Zinc Base Enables Modular Synthesis of Antimalarial Diaminopyrimidine P218 and Analogues. The Journal of organic chemistry (2023)
Carrow I Wells, Yi Liang, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean N O'Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael Miguez Couñago, Brittany Stork, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R Means, Brian York, Donald P McDonnell, John W Scott, Daniel E Frigo, David Harold Drewry
SGC-CAMKK2-1: A Chemical Probe for CAMKK2. Cells 12 (2) (2023)
Kaira C P Tomaz, Tatyana A Tavella, Joyce V B Borba, Luis C Salazar-Alvarez, João E Levandoski, Melina Mottin, Bruna K P Sousa, José T Moreira-Filho, Vitor M Almeida, Leandro C Clementino, Catarina Bourgard, Katlin B Massirer, Rafael Miguez Couñago, Carolina H Andrade, Per Sunnerhagen, Elizabeth Bilsland, Gustavo Capatti Cassiano, Fabio Trindade Maranhão Costa
Identification of potential inhibitors of casein kinase 2 alpha of Plasmodium falciparum with potent in vitro activity. Antimicrobial agents and chemotherapy (2023)
Maria Florencia Ercoli, Priscila Zonzini Ramos, Rashmi Jain, Joseph Pilotte, Oliver Xiaoou Dong, Ty Thompson, Carrow I Wells, Jonathan M Elkins, Aled M Edwards, Rafael Miguez Couñago, David Harold Drewry, Pamela C Ronald
An open source plant kinase chemogenomics set. Plant direct 6 (11) (2022)
Ricardo A M Serafim, André da Silva Santiago, Martin P Schwalm, Zexi Hu, Caio V Dos Reis, Jessica E Takarada, Priscila Mezzomo, Katlin B Massirer, Mark Kudolo, Stefan Gerstenecker, Apirat Chaikuad, Lars Zender, Stefan Knapp, Stefan A Laufer, Rafael Miguez Couñago, Alexander Titz
Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. Journal of medicinal chemistry 65 (4) (2022)
Rebeka C Fanti, Stanley N S Vasconcelos, Carolina M C Catta-Preta, Jaryd R Sullivan, Gustavo P Riboldi, Caio V Dos Reis, Priscila Z Ramos, Aled Morgan Edwards, Marcel A Behr, Rafael Miguez Couñago
A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria. ACS infectious diseases 8 (8) (2022)
Suélen Fernandes Silva, Angélica Hollunder Klippel, Priscila Zonzini Ramos, André da Silva Santiago, Sandro Roberto Valentini, Mario Henrique Bengtson, Katlin Brauer Massirer, Elizabeth Bilsland, Rafael Miguez Couñago, Cleslei Fernando Zanelli
Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major. PLoS neglected tropical diseases 14 (10) (2020)
Gustavo P Riboldi, Rachael Zigweid, Peter J Myler, Stephen J Mayclin, Rafael Miguez Couñago, Bart L Staker
Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR. RSC medicinal chemistry 12 (1) (2020)
Fernando Rodrigues de Sá Alves, Rafael Miguez Couñago, Stefan A Laufer
Chemical Space Exploration of Oxetanes. International journal of molecular sciences 21 (21) (2020)
Rafael Miguez Couñago, Charles K Allerston, Pavel Savitsky, Hatylas Azevedo, Paulo H Godoi, Carrow I Wells, Alessandra Mascarello, Fernando H de Souza Gama, Katlin B Massirer, William J Zuercher, Cristiano R W Guimarães, Opher Gileadi
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Scientific reports 7 (1) (2017)
Carrow I Wells, Nirav R Kapadia, Rafael Miguez Couñago, David Harold Drewry
In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases. MedChemComm 9 (1) (2017)