David Harold Drewry (David Drewry, D H Drewry, David H Drewry)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 69

Top Topics

Toxoplasma Gondii

Muscular Dystrophy

Top Venues

Journal of medicinal chemistry

ACS chemical neuroscience

ACS medicinal chemistry letters

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot Singh Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. bioRxiv : the preprint server for biology (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. ACS medicinal chemistry letters 15 (8) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. ACS medicinal chemistry letters 15 (8) (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot Singh Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. bioRxiv : the preprint server for biology (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J Dickmander, Tammy M Havener, Marcia K Sanders, Jason W Brown, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2. Molecules (Basel, Switzerland) 29 (17) (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot Singh Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. bioRxiv : the preprint server for biology (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. ACS medicinal chemistry letters 15 (8) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. ACS medicinal chemistry letters 15 (8) (2024)
Khoa Nguyen, Julia Boehling, Minh N Tran, Thomas Cheng, Andrew Rivera, Bridgette M Collins-Burow, Sean B Lee, David Harold Drewry, Matthew E Burow
NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types. Cancers 15 (7) (2023)
Dana M Klug, Edwin G Tse, Daniel Gedder Silva, Yafeng Cao, Susan A Charman, Jyoti Chauhan, Elly Crighton, Maria Dichiara, Chris Drake, David Harold Drewry, Flavio da Silva Emery, Lori Ferrins, Lee M Graves, Emily Hopkins, Thomas A C Kresina, Álvaro Lorente-Macías, Benjamin G Perry, Richard Phipps, Bruno Quiroga, Antonio Quotadamo, Giada N Sabatino, Anthony Sama, Andreas G Schätzlein, Quillon J Simpson, Jonathan Steele, Julia Shanu-Wilson, Peter Sjö, Paul Stapleton, Christopher J Swain, Alexandra Vaideanu, Huanxu Xie, William J Zuercher, Matthew H Todd
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus . ACS infectious diseases (2023)
Han Wee Ong, Chandi de Silva, Krisha Avalani, Frank Kwarcinski, Christopher R Mansfield, Michael Chirgwin, Anna Truong, Emily R Derbyshire, Reena Zutshi, David Harold Drewry
Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB. ACS medicinal chemistry letters 14 (12) (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Han Wee Ong, Chandi de Silva, Krisha Avalani, Frank Kwarcinski, Christopher R Mansfield, Michael Chirgwin, Anna Truong, Emily R Derbyshire, Reena Zutshi, David Harold Drewry
Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB. ACS medicinal chemistry letters 14 (12) (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Carrow I Wells, Yi Liang, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean N O'Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael Miguez Couñago, Brittany Stork, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R Means, Brian York, Donald P McDonnell, John W Scott, Daniel E Frigo, David Harold Drewry
SGC-CAMKK2-1: A Chemical Probe for CAMKK2. Cells 12 (2) (2023)
Jiung Nam, Amelia U Schirmer, Chelsea Loh, David Harold Drewry, Everardo Macias
Targeting the Divergent Roles of STK3 Inhibits Breast Cancer Cell Growth and Opposes Doxorubicin-Induced Cardiotoxicity In Vitro. Cancers 15 (10) (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience 14 (9) (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience (2023)
Thaila Fernanda Dos Reis, Patrícia Alves de Castro, Rafael Wesley Bastos, Camila Figueiredo Pinzan, Pedro Filho Noronha Souza, Suzanne Ackloo, Mohammad Anwar Hossain, David Harold Drewry, Sondus Alkhazraji, Ashraf S Ibrahim, Hyunil Jo, Jorge D Lightfoot, Emily M Adams, Kevin K Fuller, William F deGrado, Gustavo Henrique Goldman
A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi. Nature communications 14 (1) (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Frances M Bashore, Ariana B Marquez, Apirat Chaikuad, Stefanie Howell, Andrea S Dunn, Alvaro A Beltran, Jeffery L Smith, David Harold Drewry, Adriana S Beltran, Alison D Axtman
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis. Scientific reports 13 (1) (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience 14 (9) (2023)
Carrow I Wells, Yi Liang, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean N O'Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael Miguez Couñago, Brittany Stork, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R Means, Brian York, Donald P McDonnell, John W Scott, Daniel E Frigo, David Harold Drewry
SGC-CAMKK2-1: A Chemical Probe for CAMKK2. Cells 12 (2) (2023)
Frances M Bashore, Joel K Annor-Gyamfi, Yuhong Du, Vittorio Katis, Felix Nwogbo, Raymond G Flax, Stephen V Frye, Kenneth H Pearce, Haian Fu, Timothy M Willson, David Harold Drewry, Alison D Axtman
Fused Tetrahydroquinolines Are Interfering with Your Assay. Journal of medicinal chemistry (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Han Wee Ong, Chandi de Silva, Krisha Avalani, Frank Kwarcinski, Christopher R Mansfield, Michael Chirgwin, Anna Truong, Emily R Derbyshire, Reena Zutshi, David Harold Drewry
Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB. ACS medicinal chemistry letters 14 (12) (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience 14 (9) (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience 14 (9) (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience 14 (9) (2023)
Carrow I Wells, Yi Liang, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean N O'Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael Miguez Couñago, Brittany Stork, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R Means, Brian York, Donald P McDonnell, John W Scott, Daniel E Frigo, David Harold Drewry
SGC-CAMKK2-1: A Chemical Probe for CAMKK2. Cells 12 (2) (2023)
Zachary W Davis-Gilbert, Andreas Krämer, James E Dunford, Stefanie Howell, Filiz Senbabaoglu, Carrow I Wells, Frances M Bashore, Tammy M Havener, Jeffery L Smith, Mohammad Anwar Hossain, Udo Oppermann, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2. ACS medicinal chemistry letters 14 (4) (2023)
Brian Anderson, Peter Rosston, Han Wee Ong, Mohammad Anwar Hossain, Zachary W Davis-Gilbert, David Harold Drewry
How many kinases are druggable? A review of our current understanding. The Biochemical journal 480 (16) (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience (2023)
Maria Florencia Ercoli, Priscila Zonzini Ramos, Rashmi Jain, Joseph Pilotte, Oliver Xiaoou Dong, Ty Thompson, Carrow I Wells, Jonathan M Elkins, Aled M Edwards, Rafael Miguez Couñago, David Harold Drewry, Pamela C Ronald
An open source plant kinase chemogenomics set. Plant direct 6 (11) (2022)
Kareem A Galal, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M Havener, Michael E Chirgwin, Eric Merten, Han Wee Ong, Caleb Willis, Ahmad Abdelwaly, Mohamed A Helal, Emily R Derbyshire, Reena Zutshi, David Harold Drewry
Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial Pf GSK3/ Pf PK6 with Activity against Blood Stage Parasites In Vitro. Journal of medicinal chemistry 65 (19) (2022)
David Harold Drewry, Frances M Bashore, Armin Bayati, Jeffery L Smith, Rebekah J Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M Min, Mohammad Anwar Hossain, Mark Heise, Peter S McPherson, Nathaniel J Moorman, Alison D Axtman
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses. Journal of medicinal chemistry 65 (19) (2022)
Christopher R M Asquith, Louisa Temme, Michael P East, Tuomo Laitinen, Julie E Pickett, Frank E Kwarcinski, Parvathi Sinha, Carrow I Wells, Gary L Johnson, Reena Zutshi, David Harold Drewry
Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype. ChemMedChem 17 (12) (2022)
Deanna Marie Tiek, Beril Erdogdu, Roham Razaghi, Lu Jin, Norah Sadowski, Carla Alamillo-Ferrer, J Robert Hogg, Bassem R Haddad, David Harold Drewry, Carrow I Wells, Julie E Pickett, Xiao Song, Anshika Goenka, Bo Hu, Samuel A Goldlust, William J Zuercher, Mihaela Pertea, Winston Timp, Shi-Yuan Cheng, Rebecca B Riggins
Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas. Science advances 8 (25) (2022)
Anna Cichońska, Balaguru Ravikumar, Robert J Allaway, Fangping Wan, Sungjoon Park, Oleksandr Isaev, Shuya Li, Michael Mason, Andrew Lamb, Ziaurrehman Tanoli, Minji Jeon, Sunkyu Kim, Mariya Popova, Stephen J Capuzzi, Jianyang Zeng, Kristen Dang, Gregory Koytiger, Jaewoo Kang, Carrow I Wells, Timothy M Willson, null null, Tudor I Oprea, Avner Schlessinger, David Harold Drewry, Gustavo Stolovitzky, Krister Wennerberg, Justin Guinney, Tero Aittokallio
Crowdsourced mapping of unexplored target space of kinase inhibitors. Nature communications 12 (1) (2021)
Benjamin J Eduful, Sean N O'Byrne, Louisa Temme, Christopher R M Asquith, Yi Liang, Alfredo Picado, Joseph R Pilotte, Mohammad Anwar Hossain, Carrow I Wells, William J Zuercher, Carolina M C Catta-Preta, Priscila Zonzini Ramos, André de S Santiago, Rafael M Couñago, Christopher G Langendorf, Kévin Nay, Jonathan S Oakhill, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Timothy M Willson, Daniel E Frigo, John W Scott, David Harold Drewry
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. Journal of medicinal chemistry 64 (15) (2021)
Carrow I Wells, Hassan Al-Ali, David M Andrews, Christopher R M Asquith, Alison D Axtman, Ivan Dikic, Daniel V Ebner, Peter Ettmayer, Christian Fischer, Mathias Frederiksen, Robert E Futrell, Nathanael S Gray, Stephanie B Hatch, Stefan Knapp, Ulrich Lücking, Michael Michaelides, Caitlin E Mills, Susanne Müller, Dafydd Owen, Alfredo Picado, Kumar S Saikatendu, Martin Schröder, Alexandra Stolz, Mariana Tellechea, Brandon J Turunen, Santiago Vilar, Jinhua Wang, William J Zuercher, Timothy M Willson, David Harold Drewry
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. International journal of molecular sciences 22 (2) (2021)
Nadine Russ, Martin Schröder, Benedict-Tilman Berger, Sebastian Mandel, Yagmur Aydogan, Sandy Mauer, Christian Pohl, David Harold Drewry, Apirat Chaikuad, Susanne Müller, Stefan Knapp
Design and Development of a Chemical Probe for Pseudokinase Ca2+/calmodulin-Dependent Ser/Thr Kinase. Journal of medicinal chemistry 64 (19) (2021)
Andreas S Kalogirou, Michael P East, Tuomo Laitinen, Chad D Torrice, Kaitlyn A Maffuid, David Harold Drewry, Panayiotis A Koutentis, Gary L Johnson, Daniel J Crona, Christopher R M Asquith
Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors. Molecules (Basel, Switzerland) 26 (19) (2021)
David Harold Drewry, Joel K Annor-Gyamfi, Carrow I Wells, Julie E Pickett, Verena Dederer, Franziska Preuss, Sebastian Mathea, Alison D Axtman
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. Journal of medicinal chemistry (2021)
Ami Ketley, Marzena Wojciechowska, Sonja Ghidelli-Disse, Paul Bamborough, Tushar K Ghosh, Marta Lopez Morato, Saam Sedehizadeh, Naveed Altaf Malik, Zhenzhi Tang, Paulina Powalowska, Matthew K Tanner, Rudolf Billeter-Clark, Rebecca C Trueman, Philippine C Geiszler, Alessandra Agostini, Othman Othman, Markus Boesche, Marcus Bantscheff, Martin Rüdiger, Danuta E Mossakowska, David Harold Drewry, William J Zuercher, Charles A Thornton, Gerard Drewes, Iain Uings, Christopher J Hayes, J David Brook
CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model. Science translational medicine 12 (541) (2021)
Carrow I Wells, James D Vasta, Cesear R Corona, Jennifer Wilkinson, Chad A Zimprich, Morgan R Ingold, Julie E Pickett, David Harold Drewry, Kathryn M Pugh, Marie K Schwinn, Byounghoon Brian Hwang, Hicham Zegzouti, Kilian V M Huber, Mei Cong, Poncho L Meisenheimer, Timothy M Willson, Matthew B Robers
Quantifying CDK inhibitor selectivity in live cells. Nature communications 11 (1) (2020)
Tigist Y Tamir, David Harold Drewry, Carrow I Wells, Michael B Major, Alison D Axtman
PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor. Scientific reports 10 (1) (2020)
Andrea I Krahn, Carrow I Wells, David Harold Drewry, Lenore K Beitel, Thomas M Durcan, Alison D Axtman
Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases. ACS chemical neuroscience 11 (13) (2020)
Alfredo Picado, Apirat Chaikuad, Carrow I Wells, Safal Shrestha, William J Zuercher, Julie E Pickett, Frank E Kwarcinski, Parvathi Sinha, Chandi S de Silva, Reena Zutshi, Shubin Liu, Natarajan Kannan, Stefan Knapp, David Harold Drewry, Timothy M Willson
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. Journal of medicinal chemistry 63 (23) (2020)
Martin Schröder, Panagis Filippakopoulos, Martin P Schwalm, Carla A Ferrer, David Harold Drewry, Stefan Knapp, Apirat Chaikuad
Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3. International journal of molecular sciences 21 (21) (2020)
Alice L Herneisen, Saima M Sidik, Benedikt M Markus, David Harold Drewry, William J Zuercher, Sebastian Lourido
Identifying the Target of an Antiparasitic Compound in Toxoplasma Using Thermal Proteome Profiling. ACS chemical biology 15 (7) (2020)
Gerson S Profeta, Caio V Dos Reis, André da Silva Santiago, Paulo H C Godoi, Angela M Fala, Carrow I Wells, Roger Sartori, Anita P T Salmazo, Priscila Zonzini Ramos, Katlin B Massirer, Jonathan M Elkins, David Harold Drewry, Opher Gileadi, Rafael M Couñago
Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors. Scientific reports 9 (1) (2019)
Christopher R M Asquith, Benedict-Tilman Berger, Jing Wan, James M Bennett, Stephen J Capuzzi, Daniel J Crona, David Harold Drewry, Michael P East, Jonathan M Elkins, Oleg Fedorov, Paulo H Godoi, Debra M Hunter, Stefan Knapp, Susanne Müller, Chad D Torrice, Carrow I Wells, H Shelton Earp, Timothy M Willson, William J Zuercher
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). Journal of medicinal chemistry 62 (5) (2019)
H Christian Eberl, Thilo Werner, Friedrich B M Reinhard, Stephanie Lehmann, Douglas Thomson, Peiling Chen, Cunyu Zhang, Christina Rau, Marcel Muelbaier, Gerard Drewes, David Harold Drewry, Marcus Bantscheff
Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells. Scientific reports 9 (1) (2019)
Christopher R M Asquith, Kaleb M Naegeli, Michael P East, Tuomo Laitinen, Tammy M Havener, Carrow I Wells, Gary L Johnson, David Harold Drewry, William J Zuercher, David C Morris
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma. Journal of medicinal chemistry 62 (9) (2019)
Luigi Racioppi, Erik Russell Nelson, Wei Huang, Debarati Mukherjee, Scott A Lawrence, William Lento, Anna Maria Masci, Yiquin Jiao, Sunghee Park, Brian York, Yaping Liu, Amy E Baek, David Harold Drewry, William J Zuercher, Francesca Romana Bertani, Luca Businaro, Joseph Geradts, Allison Hall, Anthony R Means, Nelson Chao, Ching-Yi Chang, Donald P McDonnell
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nature communications 10 (1) (2019)
Daniel M Foulkes, Dominic P Byrne, Wayland Yeung, Safal Shrestha, Fiona P Bailey, Samantha Ferries, Claire E Eyers, Karen Keeshan, Carrow I Wells, David Harold Drewry, William J Zuercher, Natarajan Kannan, Patrick A Eyers
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. Science signaling 11 (549) (2018)
Dominic P Byrne, Yong Li, Krithika Ramakrishnan, Igor L Barsukov, Edwin Alexander Yates, Claire E Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow I Wells, David Harold Drewry, William J Zuercher, Neil G Berry, David G Fernig, Patrick A Eyers
New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors. The Biochemical journal 475 (15) (2018)
Dominic P Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E Eyers, Carrow I Wells, David Harold Drewry, William J Zuercher, Neil G Berry, David G Fernig, Patrick A Eyers
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors. The Biochemical journal 475 (15) (2018)
David Harold Drewry, Carrow I Wells, David M Andrews, Richard Angell, Hassan Al-Ali, Alison D Axtman, Stephen J Capuzzi, Jonathan M Elkins, Peter Ettmayer, Mathias Frederiksen, Opher Gileadi, Nathanael Gray, Alice Hooper, Stefan Knapp, Stefan Laufer, Ulrich Luecking, Michael Michaelides, Susanne Müller, Eugene Muratov, R Aldrin Denny, Kumar S Saikatendu, Daniel K Treiber, William J Zuercher, Timothy M Willson
Progress towards a public chemogenomic set for protein kinases and a call for contributions. PloS one 12 (8) (2017)
Carrow I Wells, Nirav R Kapadia, Rafael Miguez Couñago, David Harold Drewry
In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases. MedChemComm 9 (1) (2017)