Longitudinal Molecular Profiling of Circulating Tumor Cells in Metastatic Renal Cell Carcinoma.
Matthew L BootsmaRana R McKayHamid EmamekhooRory M BadeJennifer L SchehrMatthew C ManninoAnupama SinghSerena K WolfeZachery D SchultzJamie M SpergerWanling XieSabina SignorettiChristos E KyriakopoulosDavid KosoffEdwin J AbelKyle T HelzerNicholas RydzewskiHamza BakhtiarYue ShiGrace BlitzerMichael BassettiJohn M FlobergMenggang YuNan SethakornMarina N SharifiPaul M HarariToni K ChoueiriJoshua M LangShuang G ZhaoPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
In the first large longitudinal CTC study in mRCC to date to our knowledge, we identified the prognostic importance of CTC enumeration and the change over time of both CTC enumeration and the HP ratio. These insights into changes in both tumor burden and the molecular profile of tumor cells in response to different treatments provide potential biomarkers to predict and monitor response to immunotherapy in mRCC.