Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer.

Bingnan ZhangC Allison StewartQi WangRobert J CardnellPedro RochaJunya FujimotoLuisa M Solis SotoRunsheng WangVeronica NovegilPeter AnsellLei HeLuisa FernandezAdam JendrisakCole GilbertsonJoseph D SchonhoftJiyun ByunJoshua JonesAmanda K L AndersonAna AparicioHai TranMarcelo V NegraoJianjun ZhangWei-Lien WangIgnacio I WistubaJing WangRick WenstrupLauren Averett Byers Carl M Gay

Published in: British journal of cancer (2022)

SLFN11 levels can be monitored in CTCs from SCLC patients using non-invasive liquid biopsies. The ability to detect SLFN11 in CTCs from SCLC patients adds a valuable tool for the detection and longitudinal monitoring of this promising biomarker.

Keyphrases

small cell lung cancer
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
circulating tumor cells
patient reported outcomes
induced apoptosis
poor prognosis
ionic liquid
cross sectional
long non coding rna
endoplasmic reticulum stress
binding protein